【摘要】 目的分析肝动脉化疗栓塞后血清鳞状细胞癌抗原(SCCA)、磷脂酰肌蛋白聚糖3(GPC3)的浓度变化及对肝癌预后的作用。方法收集肝癌患者50例为肝癌组,均行经肝动脉化疗栓塞治疗,同期纳入50例健康体检者为健康组,比较健康组与肝癌组的血清SCCA和GPC3浓度,及治疗后肝癌患者不同疗效组及不同转移复发程度组的血清SCCA和GPC3浓度。结果治疗前,健康组的血清SCCA、GPC3浓度低于肝癌组(P﹤0.05);治疗后,肝癌患者血清SCCA和GPC3浓度比较,有效组﹤稳定组﹤进展组(P﹤0.05),低复发转移倾向组血清SCCA、GPC3浓度低于高复发转移倾向组(P﹤0.05)。结论通过检测肝癌患者经肝动脉化疗栓塞后血清SCCA、GPC3的浓度变化,将有利于判断疗效及肿瘤复发、转移情况,并评估患者预后。更多还原

【Abstract】 Objective To analyze the change of concentration of serum squamous cell carcinoma antigen(SCCA)and glypican 3(GPC3) in hepatic carcinoma after transcatheter arterial chemoembolization(TACE) and the effect on prognosis. Method 50 cases of hepatic carcinoma were enrolled as study group, treated with TACE, and 50 cases of healthy adults were included as control group, and then the serum concentrations of SCCA and GPC3 in patients with different response, metastasis and recurrence status were compared. Result Before treatment, the serum concentrations of SCCA, GPC3 were lower in control group than study group(P<0.05), while in study group, patients with response had lower level of SCCA and GPC3 than those with stable or progressive disease(P<0.05); Besides, patients with lower potential of relapse or metastasis had lower serum levels of SCCA and GPC3 than those with higher potential(P<0.05). Con Conclusion By detecting the serum concentration change of SCCA and GPC3 in hepatic carcinoma patients after TACE therapy, it is conducive to assess the curative effect and tumor recurrence and metastasis, facilitating the evaluation of prognosis.更多还原