【摘要】 目的探讨不同级别宫颈病变HPV的感染状态,人乳头瘤病毒(HPV)和宫颈脱落细胞学(TCT)检查在筛查宫颈病变中的临床应用价值。方法回顾性分析从2012年10月至2013年5月就诊于清华大学第一附属医院妇科门诊的301例可疑宫颈病变妇女的资料。这些妇女因细胞学异常(不能明确意义的非典型鳞状细胞或更高级别病变)或/和宫颈HPV-DNA检测异常(HPV-16或18亚型阳性),或宫颈细胞学检查正常但查体高度可疑病变而行阴道镜下活检。计量资料以均数及标准差表示,计数资料以頻数及百分比表示,SPSS-18.0统计软件对计数资料进行卡方或Fisher确切概率法分析。结果 301例患者中,1TCT结果:正常54例,不能明确意义的非典型鳞状细胞(ASCUS)121例,不除外高度病变的非典型鳞状细胞(ASCUS-H)25例,低度鳞状上皮内病变(LSIL)77例,高度鳞状上皮内病变(HSIL)14例,不典型腺细胞(ASGUS)2例,宫颈癌8例;2HPV感染率:总的HPV感染率为80.7%,共检测到14种HPV-DNA亚型,感染率由高到低的前五种亚型依次为HPV-16、52、18、58、53;3HPV在宫颈炎组、宫颈上皮内瘤变(CIN)Ⅰ级、CINⅡ-Ⅲ级、宫颈浸润癌组的感染率分别为69.7%、79.1%、94.7%、100%。结论随着宫颈组织学结果的严重程度的升级,宫颈HPV感染的检出率增加。更多还原

【Abstract】 Objective To investigate human papillomavirus(HPV)infection status in different grasde cervical lesions;the value of cervical liquid-based cytology(TCT)and human papillomavirus(HPV)testing for the screening of cervical lesions.Methods The colposcopy data of 301 women with suspected cervical lesions were retrospectively analyzed.These women who came for gynecological care were diagnosed with colposcopy and biopsy due to abnormal TCT and/or HPV testing in the First Hospital of Tsinghua University from October 2012 to May 2013.Abnormal result included atypical squamous cell of undetermined significance(ASCUS)or higher level lesions in TCT,positive HPV-16or-18 subtypes,or abnormal cervical appearance although with normal TCT.SPSS18.0 software was used for statistic analysis,Chi-square or Fisher exact test was used for categorical variable as appropriate.Results Of 301 patients,1TCT result were categorized with normal of 54,ASCUS of 121,low-grade squamous intra-epithelial lesion(LSIL)of 77,high-grade squamous intra-epithelial lesion(HSIL)of 14,ASCUS that cannot exclude HSIL(ASCUS-H)of 25,atypical glandular cells of undetermined significance(AGUS)of 2,and cancer of 8;2HPV infection rate was 80.7% in total and 14 kinds of HPV-DNA subtypes were detected.The most popular subtypes were HPV-16、52、18、58、53in declined order.The HPV infection rates were 69.7%、79.1%、94.7%、100% among cervicitis,cervical intra-epithelial neoplasia(CIN)Ⅰ,CINⅡ-Ⅲ,and cervical carcinoma respectively.Conclusion HPV infection rate increased with the increasing severity of the cervical histology results.更多还原