【摘要】 【目的】探讨内源性尿激酶受体(u-PAR)对急性冠脉综合征患者经皮冠状动脉介入治疗(PCI)预后的预测作用。【方法】分析2005年6月-2006年8月在我院心内科行PCI的急性冠脉综合征(ACS)103例,分别检测患者入院时及入院2周后全血中性粒细胞表面u-PAR表达率,并按入院时全血中性粒细胞表面u-PAR表达率水平分组,评估发生主要不良心血管事件(MACE)包括死亡、致命性或非致命性心肌梗死的风险。【结果】平均随访6.5年,发生全因死亡12例,致命性心肌梗死2例,非致命性心肌梗死8例。全血中性粒细胞表面u-PAR表达率低、中、高组的MACE发生率分别为9.1%、17.1%、31.4%,单因素及多因素分析结果均显示全血中性粒细胞表面u-PAR表达率是MACE的独立预测因子,分别为:HR=2.15,95%CI(1.30,3.54),P=0.003;HR=2.07,95%CI(1.25,3.44),P=0.005。【结论】u-PAR对ACS患者经PCI治疗后的MACE有预测作用。更多还原

【Abstract】 【Objective】 To explore the prognostic value of urokinase-type plasminogen activator receptor(u-PAR) in predicting major adverse cardiovascular events(MACE) in the patients with acute coronary syndrome(ACS) undergoing percutaneous coronary intervention(PCI). 【Methods】 A total of 103 patients with ACS undergoing PCI in cardiology department of the Third Affiliated Hospital of SUN Yat-sen University from Jun 2005 to Aug 2006 were enrolled. In all these patients, the expression levels of u-PAR on neutrophile were measured by flow cytometry when the cases were admitted to hospital and two weeks after. These patients were divided into three groups according to the u-PAR Levels: low u-PAR group, intermediate u-PAR group and high u-PAR group. The endpoints were all-cause mortality and fatal or nonfatal recurrent myocardial infarction(MI). 【Results】 During a median follow-up period of 6.5years, 12 all-cause mortality, 2 fatal and 8 nonfatal recurrent MIs occurred. MACE rates of low, intermediate, and high u-PAR Levels group were 9.1%, 17.1%, and 31.4%, respectively. Both univariate analysis and multivariate analysis showed that the u-PAR was an independent predictor of MACE [HR = 2.15, 95%CI(1.30, 3.54), P = 0.003]; [HR = 2.07, 95%CI(1.25, 3.44), P = 0.005].【Conclusions】 u-PAR could be an independent risk predictor of major adverse cardiovascular events among patients with acute coronary syndrome undergoing percutaneous coronary intervention.更多还原