【摘要】 目的探讨HIV感染者服用复方磺胺甲噁唑(Co-SMZ)后诱发超敏反应的可能因素。方法采用回顾性研究的方法,对74例HIV感染并服用Co-SMZ患者的年龄、性别、入院时HIV发现的时间间隔、CD3~+T细胞、CD4~+T细胞、CD8~+T细胞、NK细胞计数以及合并用药情况进行分析,探明可能诱发Co-SMZ相关超敏反应的因素。入组患者中,治疗性使用Co-SMZ患者56例;预防性使用CoSMZ患者18例。结果在发生超敏反应和未发生超敏反应人群中,性别、年龄的分布、入院时与发现HIV感染时间间隔、CD3~+T细胞、CD8~+T细胞计数,联合使用哌拉西林他唑巴坦、头孢他啶、头孢吡肟、亚胺培南西司他丁、替考拉宁、氟康唑、甲泼尼龙、抗HIV药物以及Co-SMZ使用剂量等方面差异均无统计学意义(P均>0.05);CD4~+T细胞、NK细胞表达水平计数,联合使用莫西沙星例数在两组患者差异有统计学意义(P<0.05);CD4~+T细胞、NK细胞能预测Co-SMZ相关超敏反应的发生(Z=2.872、2.836,P均<0.05)。结论在HIV感染者中,Co-SMZ诱发超敏反应的发生可能与CD4~+T细胞、NK细胞计数以及是否合并使用莫西沙星有关。更多还原

【Abstract】 Objective To investigate the related factors of hypersensitivity induced by compound sulfamethoxazole(Co-SMZ) in patients with human immunodeficiency virus(HIV) infection.Methods Total of 74 patients receiving Co-SMZ with HIV infection were enrolled in the study.The age,gender,interval time from finding HIV infection to hospitalization,the count of CD3~+ T cell,CD4~+ T cell,CD4~+T cell and NK cell,and the combined drugs were analyzed,respectively.Retrospective method was taken in the study.There were 56 patients with Co-SMZ treatment and 18 patients with preventive use.Results There were no significant differences in the age,gender,interval time from finding HIV infection to hospitalization,the count of CD3~+ T cell,CD4~+ T cell,combined of piperacillin tazobactam,ceftazidime,cefepime,imipenem-cilastatin,teicoplanin,fluconazole,methyl prednisolone or the anti-HIV drugs,the dose of Co-SMZ between patients with Co-SMZ related hypersensitivity and patients without Co-SMZ related hypersensitivity(P all > 0.05).Significant difference was found in the count of CD4~+ T cell,NK cell and moxifloxacin in combination among the two groups(P < 0.05).The count of CD4~+ T cell,NK cell could predict the occurrence of hypersensitivity induced by Co-SMZ(Z = 2.872,2.836;P all < 0.05).Conclusions Among patients with HIV infection,the count of CD4~+ T cell,NK cell and moxifloxacin in combination might be associated with the hypersensitivity induced by Co-SMZ.更多还原