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以他汀类药物为基础的降脂药物联合应用研究进展
Progress in statin based combination lipid therapy
【摘要】 降脂治疗是预防动脉粥样硬化性心血管疾病的基石,其主要目标是降低低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇。目前他汀类药物仍是降脂治疗的首选。然而,在临床实践中,许多患者单用他汀类药物治疗其血脂水平仍不能达标。而降脂药物联合应用不仅增加疗效,且可能减少不良反应。本文对以他汀类药物为基础的降脂药物联合应用的临床研究进展进行了综述。
【Abstract】 Lipid-lowering therapy is the foundation for atherosclerotic cardiovascular disease prevention and the primary goal is to reduce the LDL-C and non-HDL-C. Although statins are still the first treatment option for dyslipidemia, many patients treated with statins alone do not reach the lipid goals recommended by guidelines. Combination lipid therapy not only improves the efficacy, but also has fewer side effects. In this article, we reviewed the clinical research progress in statin based combination lipid therapy.
【关键词】 联合降脂治疗;
他汀类药物;
依折麦布;
前蛋白转化酶枯草溶菌素9抑制剂;
贝特类;
烟酸类;
ω-3脂肪酸;
【Key words】 combination lipid therapy; statin; ezetimibe; PCSK9 inhibitor; fibrates; niacin; ω-3 free fatty acid;
【Key words】 combination lipid therapy; statin; ezetimibe; PCSK9 inhibitor; fibrates; niacin; ω-3 free fatty acid;
- 【文献出处】 中南药学 ,Central South Pharmacy , 编辑部邮箱 ,2015年11期
- 【分类号】R972.6
- 【被引频次】17
- 【下载频次】432