【摘要】 目的研究胃癌组织中CC趋化因子17(CCL17)及CC趋化因子受体4(CCR4)的表达及临床意义。方法收集经手术病理证实的胃癌患者55例(男41例,女14例,中位年龄62岁),健康对照组20例(男13例,女7例,中位年龄为61岁),应用免疫组化方法检测CCL17、CCR4在胃癌、癌旁组织及正常胃组织中的表达,并根据显微镜视野中阳性细胞所占的比例评分阐明胃癌组织中CCL17、CCR4的表达与临床、病理参数的相关性。结果胃癌组织中CCL17和CCR4的表达强度明显高于癌旁组织和正常胃组织,癌旁组织和正常胃组织两者的表达强度无明显差异。胃癌组织中CCL17及CCR4的表达与肿瘤分期有关(P<0.05),两者均与患者年龄、性别、分化程度等无关。结论 CCL17及CCR4在胃癌发生、发展中发挥一定作用。更多还原

【Abstract】 Objective To study the expression and clinical significance of chemokine(C-C motif) ligand 17(CCL17) and CC chemokine receptor 4(CCR4) in gastric cancer. Methods 55 cases of pathologically confirmed gastric cancer patients(41 cases of male, 14 cases of females, mean age of 62 years) were enrolled and 20 cases of healthy persons were chosen as the control group(13 males, 7 females, mean age of 61 years). Immunohistochemical method was used to detect the expression of CCL17 and CCR4 in gastric cancer tissues, adjacent cancer tissues as well as in normal gastric tissues; then, the correlation between the expression of CCL17 and CCR4 in gastric tissues and clinical and pathological variables were analyzed. Results The expression of CCL17 and CCR4 in gastric carcinoma tissues was significantly higher than the control gastric tissue and adjacent cancer tissues, while, the expression of both showed no significant difference between the adjacent cancer tissues and the control group. The expression of CCL17 and CCR4 was positively related to tumor TNM staging(P<0.05), but had no correlation with age, gender and degree of differentiation. Conclusion CCL17 and CCR4 play an important role in gastric carcinogenesis and development.更多还原