【摘要】 目的观察胰岛β细胞分泌功能与胰岛素抵抗指数(HOMA-IR)在T2DM中的变化。方法T2DM患者268例,行75g OGTT或100g馒头餐试验,以及C-P释放试验,比较组间各项相关指标的差异。结果与病程<5年组比较,病程>10年组胰岛β细胞功能(HOMA-β)下降(P<0.05)。病程>10年组随FPG增加,HOMA-β下降(P<0.01),HOMA-IR增加,但差异无统计学意义(P>0.05)。结论长期良好的控制血糖,可延缓胰岛β细胞功能的衰竭。病程对HOMA-β的损伤低于高血糖。更多还原

【Abstract】 Objective To evaluateβcell function,insulin resistance and their changes in patients with type 2diabetes mellitus(T2DM). Methods A total of 268T2 DM patients were enrolled in this study.75 g OGTT or 100 g steamed bread meal test and C-peptide release test were measured in all the subjects. Results Theβcell function index(HOMA-β)decreased significantly during the progress of T2DM(P<0.05).In T2 DM duration>10years group,the decrease of HOMA-βand the increase in HOMA-IR associated with the increase of FPG did not reach the significant difference(P >0.05).Together with the raising of FPG level,HOMA-βdecreased,and the HOMA-IR increased significantly(P<0.01). Conclusion Long-term,well-controlled blood glucose could delay the exhaustion ofβcell function.Injury toβcell function based on duration of diabetes is less severe than that of hyperglycemia.更多还原