【摘要】 目的分析2013年媒体报道的乙型肝炎疫苗(Hepatitis B Vaccine,Hep B)事件中,湖南省3例接种Hep B后出现的疑似预防接种异常反应(Adverse Events Following Immunization,AEFI),为今后AEFI的处理提供参考。方法根据现场调查、临床资料及婴儿尸检报告、疫苗检验结果等进行分析。结果 2例接种Hep B后死亡,均为其他原因所致,与接种Hep B无关;1例接种Hep B同时注射1剂维生素K1,过敏性休克可能性大,过敏原是Hep B还是维生素K1无法确定。结论及时、客观的处理AEFI,适时发布权威信息,对于增加公众信任,减少社会负面影响,保持预防接种有序开展有重要作用。更多还原

【Abstract】 Objective Analyze the three cases of adverse events following immunization( AEFI) with hepatitis B vaccine in Hunan that were reported by the media in 2013 to provide a reference for handling future AEFIs. Methods We analyzed data from field investigation,clinical treatment records,and autopsy reports in conjunction with conclusions from the investigation of the vaccine. Results Two babies died following immunization with hepatitis B vaccine alone. According to the autopsy results,their causes of death were unrelated to hepatitis B vaccination practices. The third baby had been vaccinated with hepatitis B vaccine given simultaneously with vitamin K1. In this case,the most likely cause of death was anaphylactic shock,but it was not clear whether the allergen was hepatitis B vaccine or vitamin K1. Conclusion Dealing with AEFI objectively and in a timely manner,along with proper and immediate distribution of information from authorities,plays a crucial role in enhancing public trust,reducing negative social impact,and maintaining immunization program practices.更多还原