【摘要】 目的探讨过敏性结膜炎患者TGF-β1和IL-17的表达水平。方法对我院治疗的过敏性结膜炎患者和健康人群的TGF-β1和IL-17的表达水平进行检测,探讨在各型过敏性结膜炎患者中的表达强度。结果过敏性结膜炎患者TGF-β1和IL-17水平高于健康人群,差异有统计学意义(P<0.01),过敏性结膜炎四个临床亚型中TGF-β1和IL-17的表达水平不一,以春季角结膜炎表达水平最高,其次为常年性过敏性结膜炎和季节性过敏性结膜炎,特应性角结膜炎表达水平最低,但四个临床亚型组间比较差异无统计学意义(P>0.05)。结论过敏性结膜炎患者TGF-β1和IL-17表达水平高于正常健康人群。TGF-β1和IL-17在各型过敏性结膜炎患者中表达强度不同,在春季角结膜炎表达水平明显高于其他类型。更多还原

【Abstract】 Objective To investigate the expression level of transforming growth factor β1(TGF-β1) and interleukin 17(IL-17) in patients with allergic conjunctivitis. Methods TGF-β1 and IL-17 expression levels in allergic conjunctivitis patients hospitalized in the author’s hospital and a healthy population were detected to explore the expression level in all types of patients with allergic conjunctivitis. Results TGF-β1 and IL-17 levels were significantly higher in patients with allergic conjunctivitis than in healthy population(P<0.01). Among the four clinical subtypes of allergic conjunctivitis, vernal keratoconjunctivitis had the highest expression level of TGF-β1 and IL-17 in spring, followed by perennial allergic conjunctivitis and seasonal allergic conjunctivitis, and atopic keratoconjunctivitis had the lowest expression level. However, the differences among the four subtypes were not significant(P>0.05). Conclusion Patients with allergic conjunctivitis have higher TGF-β1 and IL-17 expression levels than normal healthy people. TGF-β1 and IL-17 expression level vary in different subtypes of allergic conjunctivitis, vernal keratoconjunctivitis has higher expression level than other types in spring.更多还原