【摘要】 目的探讨乳腺浸润性微乳头状癌(IMPC)(黏液亚型)的临床病理特征、诊断与鉴别诊断。方法分析2例乳腺黏液亚型浸润性微乳头状癌临床资料,观察其组织学形态及免疫表型特征,并复习相关文献。结果 2例均为中、老年女性,均以发现乳腺肿块就诊。组织学显示,肿瘤细胞呈微乳头状,漂浮在黏液中,瘤细胞外周有一透明的腔隙。免疫组化:Her-2(3+),腺体外周EMA(+),ER、PR和EGFR(-),Ki-67增殖指数为30%。Her-2的FISH检测结果为(+)。结论乳腺浸润性微乳头状癌(黏液亚型)是一种罕见的预后差的乳腺恶性肿瘤,需要与乳腺单纯型黏液癌进行鉴别,依据临床和病理组织学特点,结合免疫组化染色可以明确诊断。更多还原

【Abstract】 Objective To explore the clinicopathological features,diagnosis and differential diagnosis of mucinous subtype of invasive micropapillary carcinoma( IMPC) of the breast. Methods By analysis of the clinical data in 2 cases of IMPC,the histological morphology and immunohistochemical characteristics of IMPC were studied,and their relevant literatures were reviewed. Results The female patients were 64 and 54 years old,respectively. Both presented with a mass found in the left breast. Histologically,the tumor presented a micropapillary architectural pattern floating in the mucus,with a transparent lacuna around the tumor cells. Immunohistochemically,both showed ER(-),PR(-),HER2( 3 +),EGFR(-),EMA( gland peripheral area +),and Ki-67 proliferation index of approximate 30%. FISH test results of HER2 amplification were positive. Conclusions The IMPC( mucinous subtype) is a rare malignant tumor of breast with a poor prognosis,which requires to be differentiated from pure mucinous breast carcinoma( PMBC). According to the clinical and histopathologic features of IMPC, definite diagnosis can be made in combination with the immunohistochemical staining.更多还原