【摘要】 目的探讨经皮射频消融(RFA)联合肝动脉栓塞化疗(TACE)序贯性治疗结直肠癌肝转移瘤的疗效。方法分析2006-06~2010-06开平市中心医院62例无法手术切除的结直肠癌肝转移瘤患者,按治疗方法分为2组:联合组(RFA联合TACE)34例,TACE组28例。观察治疗后第1周肝功能变化;治疗后4周增强CT/MRI检查肿瘤坏死率的情况;治疗后的生存率。结果 TACE组和联合组比较:1周后肝功能变化,差异无统计学意义(P>0.05);治疗后肿瘤坏死率分别为60.7%(17/28)和90.41%(32/34),差异有统计学意义(P<0.05);半年生存率分别为92.9%和97.1%,1,2,3年生存率联合组明显优于TACE组(P<0.05)。结论对于无法手术切除的结直肠癌肝转移瘤,射频消融联合肝动脉栓塞化疗的治疗效果明显优于肝动脉栓塞化疗,且安全可靠,易于操作。更多还原

【Abstract】 Objective To access the effect of sequential percutaneous radiofrequency ablation( RFA) combined with transcateter artery chemoembolization( TACE) for colorectal liver metastases.Methods From June 2006 to June 2010,62 patients with unresectable colorectal liver metastases were admitted in Kaiping Center Hospital,and then divided into two groups:combination group( RFA + TACE,n = 34) and TACE group( n = 28).After treatment,liver function at 1 week after treatment,tumor necrosis rate by enhanced CT /MRI at 4 week after treatment,and the overall survival rates were recorded.Results There was no significant difference in liver function at 1 week after treatment between these two groups( P > 0.05).The tumor necrosis rate in combination group was higher than that in TACE group at 4 weeks after treatment( 90.4% vs 60.7%,P < 0.05).The 1-,2-,3-year overall survival rates in combination group were higher than in TACE group( P < 0.05).Conclusion RFA combined with TACE is safe and effective for unresectable colorectal liver metastases.更多还原