【摘要】 目的 回顾性分析陕西省西安地区体检人群中各型肝炎病毒血清学流行情况。方法 利用酶联免疫吸附试验(ELISA)检测2009~2014年陕西省西安地区体检者血清中甲型肝炎病毒(HAV)抗体IgM,乙型肝炎病毒表面抗原(HB sAg),丙型肝炎病毒(HCV)抗体IgG,丁型肝炎病毒(HDV)抗体IgM,戊型肝炎病毒(HEV)抗体IgM和IgG。结果 1315例体检者血清中HAV IgM阳性率为0.15%(2/1 315);109 965例体检者血清中HBsAg阳性率为2.83%(3 360/109965),HBsAg阳性率总体呈下降趋势(x~2=63.070,P=0.001);各年度之间男性体检者血清中HBsAg阳性率无显著性差异(x~2=4.804,P=0.441),而各年度之间女性体检者血清中HBsAg总体阳性率逐年下降(x~2=18.046,P=0.003),男性体检者血清中HBsAg阳性率明显高于女性(x~2=126.9,P=0.000);41 898例体检者血清中HCV抗体阳性率为0.79%(333/41 898),HCV抗体阳性率逐年下降(x~2=18.380,P=0.003);1 079例体检者血清中未检测出丁型肝炎病毒抗体IgM;1 195例体检者血清中HEV IgM阳性率为0.25%(3/1 195),而HEV IgG阳性率为3.93%(47/1 195)。结论2009~2014年体检者中肝炎病毒感染以HBV和HCV为主,而且呈总体下降趋势,为陕西省西安地区各型肝炎病毒血清学流行情况提供了资料和防控依据。更多还原

【Abstract】 Objective To investigate retrospective analysis on serological detection of hepatitis viruses in physical examination population.Methods Hepatitis A virus(HAV) IgM,HBsAg,HCV IgG,HDV IgM,HEV IgM and HEV IgG were detected by ELISA assay in physical examination population during 2009~2014.Results The positive rate of HAV IgM was 0.15%(2/1 315) in 1 315 physical examinees and that of HBsAg was 2.83%(3 360/109 965) in 109 965 ones during 2009 ~ 2014.The positive rates of HBsAg decreased trend in the last 6 years in general(x~2 =63.070,P = 0.001).There was no significant difference for HBsAg positive rate among male physical examinees in last six years(x~2 =4.804,P = 0.441),but the positive rate of HBsAg in female population decreased trend in the last 6 years in general(x~2 = 18.046,P=0.003).moreover the positive rate of HBsAg in male popolatioh was significantly higher than that in female ones(x~2 = 126.9,P=0.000).The positive rate of HCV IgG was 0.79%(333/41 898) in 41 898 physical examinees during 2009 ~ 2014 and that decreased trend in last 6 years(x~2 =18.380,P = 0.003).There was no HDV IgM detected in 1 079 physical examinees serum.The positive rate of HEV IgM and IgG were 0.25%(3/1 195) and 3.93%(47/1 195) respectively in 1 195 physical examinees.Conculsion The physical examination population during 2009 — 2014 were mainly infected by HBV and HCV and the infection rate decreased trendly in last 6 years,which provided important data for epidemiology of serological hepatitis viruses in Shaanxi provice.更多还原