【摘要】 目的探讨儿童哮喘患者血清降钙素原(PCT)、C反应蛋白(CRP)水平变化及其与肺功能的相关性。方法测定60例儿童哮喘患者(急性发作期30例,缓解期30例)、30例正常对照组健康儿童血清PCT、CRP水平,并分析其与肺功能的相关性。结果儿童哮喘急性发作期患者PCT、CRP均高于缓解期患者及正常对照组,差异有统计学意义(P<0.05)。缓解期患者PCT、CRP稍高于正常对照组,但无统计学意义(P>0.05)。相关性分析提示儿童哮喘急性发作期患者PCT、CRP水平与FEV1%呈负相关(r=-0.432,P<0.01和r=-0.317,P<0.05)。结论儿童哮喘急性发作期患者血清PCT、CRP处于高水平,提示急性发作期患者存在细菌感染,能一定程度上反映其肺功能损害情况。更多还原

【Abstract】 Objective To explore the changes of serum procalcitonin( PCT) and C-reactive protein( CRP) levels in children with bronchial asthma and the correlations with the lung function. Methods The levels of PCT and CRP in serum were detected in 60 children with bronchial asthma( 30 patients in acute attack group and 30 patients in remission group) and 30 healthy children in control group,and observed the correlations between PCT,CRP with the lung function. Results The levels of PCT and CRP in acute attack group were significantly higher than remission group and control group( P < 0. 05),The levels of PCT and CRP in remission group were higher than control group,but the differences were not statistically significant( P > 0. 05). The levels of PCT and CRP in acute attack group were negatively correlated with FEV1%( r =- 0. 432,P < 0. 01 and r =- 0. 317,P < 0. 05). Conclusions The levels of PCT and CRP in children with bronchial asthma in acute attack are high,to hint there is bacterial infection,and to certain extent,it can reflect the lung function damage.更多还原