【摘要】 目的研究5种淡水鱼(青鱼、鲫鱼、黄鳝、鳊鱼和鲢鱼)摄取对女性乳腺癌发病风险的影响。方法采用病例-对照研究方法,于2004-06-01-2007-12-31在江苏省泰兴、无锡、淮安和金坛市,采用包括83个饮食项目的定量问卷表调查669例乳腺癌患者和682名健康对照的饮食状况。采用非条件Logistic回归方法分析乳腺癌的发病风险(OR)及其95%可信限(95%CI)。结果 5种鱼类合计分析显示,淡水鱼摄取降低了乳腺癌的发病风险,但无剂量-反应关系。不同种类淡水鱼分析显示,青鱼和鲢鱼的摄取量与乳腺癌的发病风险负相关,与不吃青鱼组相比,月摄取量≥500g组的调整OR为0.54,95%CI:0.33~0.92,P<0.001;与不吃鲢鱼组相比,月摄取量≥1 000g组的调整OR为0.19,95%CI:0.11~0.33,P<0.001。黄鳝的摄取量也与乳腺癌的发病风险负相关,P<0.001;但其最高摄取量组(≥500g/月)的调整OR值差异无统计学意义。而鲫鱼的摄取量与乳腺癌的发病风险正相关,与不吃鲫鱼组相比,月摄取量≥1 000g组的调整OR为6.09,95%CI:3.04~12.19,P<0.001。鳊鱼的月摄取量与乳腺癌的发病风险无相关性,但月摄取量在1~499g和500~999g组的OR显著降低,而月摄取量≥1 000g组的OR明显升高。结论淡水鱼摄取影响乳腺癌的发病风险,不同种类的淡水鱼及其摄取量对乳腺癌发病风险的影响有所不同。更多还原

【Abstract】 OBJECTIVE To investigate the association between the intake of 5species of freshwater fish(black carp,finless eel,bream,crucian carp)and silver carp and the risk of breast cancer in Chinese women.METHODS A casecontrol study was conducted with 669 cases and 682population-based controls in Jiangsu Province of China.A structured questionnaire was used to elicit detailed information.Unconditional logistic regression analysis was performed to calculate odds ratios(ORs)and 95% confidence intervals(CIs).RESULTS Total freshwater fish intake decreased the adjusted OR of breast cancer,but no dose-response relation.Analyses by freshwater fish species showed that consumption of finless eel and silver carp were inversely related to breast cancer risk,with an adjusted-OR for the highest intake category of black camp(≥500g/month)of 0.54(95%CI:0.33-0.92;P<0.001)and for the highest intake category of silver carp(≥1 000g/month)of 0.19(95%CI:0.11-0.33;P<0.001).Reduced risk was also related to high consumption of finless eel(P<0.001),but the adjusted-OR of the highest intake category(≥500g/month)was not statistically significant.In contrast,consumption of crucian carp was positively related to breast cancer risk,with an adjusted OR for the highest intake category(≥1 000g/month)of 6.09(95%CI:3.04-12.19;P<0.001).With regard to intake of bream,compared with the never intake of bream,the second and the third intake categories all had a significant decreased OR,but OR of the highest intake category(≥1 000g/month)showed a clear increase.CONCLUSION The findings of this study suggest that intakes of freshwater fish may modify risk of breast cancer,and that different species of fish and their consumption could have a different action on breast cancer risk.更多还原