【摘要】 目的:探讨卡马西平(CBZ)诱导儿童伴中央中颞区棘波的良性癫癎(BECT)发生睡眠期癫癎性电持续状态(ESES)的相关因素。方法:回顾分析219例BECT治疗过程中6例出现ESES的病历资料。结果:CBZ治疗组123例中有6例出现ESES,非CBZ治疗组96例中无ESES发生,两组发生率比较差异有统计学意义。6例ESES中,有5例出现于Rolandio区棘波组,1例出现于非棘波组,两组发生率比较差异有统计学意义。结论:CBZ能导致BECT出现ESES现象,Rolando区棘波与ESES的发生有一定相关性。更多还原

【Abstract】 Objective:To explore the correlationof carbamazepine(CBZ) with occurrence of electrical status epilepticus during sleep(ESES) in benign epilepsy with centrotemporal spikes(BECT).Methods:The clinical data of 6 patients with ESES out of 219 patients with BECT in our hospital were analyzed retrospectively.Results:The onset age of 219 children ranged from 4 years to 12 years.6 cases wilh ESES were found in 123 patients with CBZ(CBZ group).No patient who was treated with valproate or topiramate showed ESES in 96 patients(non-CBZ group).There was a significant difference between CBZ group and non-CBZ group(P<0.05).The duration of ESES disappearence in EEC examination ranged between 3 and 6 months after discontinuation of CBZ..Five cases in 6 patients with ESES suffered from centrotemporal spikes.Conclusion:CBZ can induce ESES in the treatment of BECT,although it rarely happens.There is a certain correlation between ESES and BECT with spike waves in rolandic area.更多还原