【摘要】 目的检测Kif2a,β-catenin,MMP-1在妊娠高血压患者胎盘组织中的表达,并探讨其与妊娠期高血压的关系。方法选取妊娠期高血压患者28例、子痫前期27例、正常妊娠27例胎盘组织标本,采用免疫组化检测Kif2a,β-catenin,MMP-1的表达情况。结果免疫组化显示妊娠期高血压和子痫前期患者胎盘组织中Kif2a,β-cateni,MMP-1的表达明显低于正常妊娠组(P<0.05),且3个指标在子痫前期组胎盘组织中表达低于妊娠高血压病组,差异有统计学意义(P<0.05)。在妊娠期高血压组中,Kif2a与β-catenin的表达之间呈显著正相关(r=-0.392,P=0.005);β-catenin与MMP-1的表达之间呈显著正相关(r=-0.349,P=0.008);Kif2a与MMP-1的表达之间呈显著正相关(r=-0.367,P=0.004)。结论妊娠期高血压病人胎盘Kif2a,β-catenin,MMP-1表达均明显减少,推测三者可能协同参与了妊娠期高血压的发病过程。更多还原

【Abstract】 Objective To test the expression of Kif2 a,β-catenin and MMP-1 in the human placenta of pregnancy induced hypertension syndrome(PIH) patients,and discuss its relationship with PIH.Methods The 28 cases of PIH,27 cases of pre-eclampsia and 27 placental tissue specimen of normal pregnancy were selected,and adopt immunohistochemistry to test the expression of Kif2 a,β-catenin and MMP-1.Results The immunohistochemistry indicates that the expression of Kif2 a,β-catenin and MMP-1 in the human placenta of PIH and pre-eclampsia patients isevidently under the group of normal pregnancy(P <0.05).The three index in human placenta cases are lower than in the PIH cases.The difference was statistically significant(P <0.05).In the group of PIH,the expression of Kif2 a and β-catenin has the significant positive correlation(r =-0.392,P =0.005);the expression of β-catenin and MMP-1 has the significant positive correlation(r =-0.349,P= 0.008);the expression of Kif2 a and MMP-1 has the significant positive correlation(r =-0.367,P =0.004).Conclusion The expression of Kif2 a,β-catenin and MMP-1 in the human placenta of PIH patients are significantly reduced.Speculated that Kif2 a,β-catenin and MMP-1 probably participate in the happening of PIH.更多还原