【摘要】 目的 观察支气管哮喘-慢性阻塞性肺疾病重叠综合征（ACOS）患者血清维生素D的水平情况,探讨维生素D不足或缺乏对ACOS患者的影响。方法 收集ACOS患者和同期体检健康对照者各48例,采用酶联免疫吸附试验（ELISA）法测定其血清中的25-羟维生素D[25-（OH）D]水平;将ACOS患者的急性发作频率、第1秒用力呼气容积占预计值百分比（FEV₁%）和25-（OH）D水平作相关分析。结果 ACOS患者的血清中25-（OH）D水平[（32.26±9.97）nmol/L]明显低于对照组[（51.00±14.61）nmol/L,P<0.05]。ACOS患者的25-（OH）D水平与其急性发作次数呈负相关（r=-0.70,P<0.05）,与患者FEV₁%呈正相关（r=0.68,P<0.05）。结论 维生素D不足或缺乏在ACOS患者中患病率较高,且与ACOS患者的急性发作次数和FEV₁%相关。更多还原

【Abstract】 Objective To observe the serum levels of vitamin D in patients with asthma-chronic obstructive pulmonary disease overlap syndrome（ACOS）,and to explore the effect of vitamin Ddeficiency or lack on the ACOS patients.Methods Forty-eight ACOS patients and forty-eight healthy subjects were enrolled in our study.The serum levels of 25-（OH）D were measured by enzyme-linked immunosorbent assay（ELISA）.The correlation analysis were used for the incidence of exacerbations,forced expiratory volume in one second to forced vital capacity ratio（FEV₁%） and the levels of 25-（OH） D in the ACOS patients.Results The levels of 25-（OH）D were significantly lower in the ACOS patients[（32.26 ±9.97）nmol/L]than those in the healthy subjects[（51.00 ± 14.61）nmol/L,P <0.05].25-（OH）D level was negatively correlated with the incidence of exacerbations（r =- 0.70,P < 0.05）,and positively correlated with FEV₁%（r = 0.68,P < 0.05）.Conclusion Vitamin D deficiency or lack is highly prevalent in the ACOS patients,which may be correlated with the increased incidence of exacerbations and the declined level of FEV₁%in the ACOS patients.更多还原