【摘要】 目的:观察沙利度胺联合白芍总苷胶囊治疗RAU的临床效果,检测治疗前、后血清中TNF-α、IL-2的表达水平,初步探讨沙利度胺治疗RAU的可能机制。方法:60例RAU患者随机分为两组,分别应用沙利度胺加白芍总苷胶囊(治疗组)、昆明山海棠片加白芍总苷胶囊(对照组)治疗,观察、记录临床指标并比较其疗效。获取两组患者治疗前、后的血清,应用ELISA方法检测血清中TNF-α、IL-2的含量并进行统计学检验。结果:1治疗组和对照组RAU患者在延长总间歇期、减少总溃疡数、减轻溃疡疼痛指数和缩短平均溃疡期的临床效果均较显著(P<0.05),与对照组相比,治疗组效果更显著(P<0.05);2RAU患者血清中TNF-α水平高于健康人(P<0.05),且TNF-α水平重型RAU>轻型RAU>健康人(P<0.05),而IL-2水平低于健康人(P<0.05),且IL-2水平,重型RAU<轻型RAU<健康人(P<0.05);3治疗组和对照组治疗后血清中TNF-α水平均显著降低(P<0.05),IL-2水平增高(P<0.05);且与对照组相比,治疗组改变更明显(P<0.05)。结论:沙利度胺加白芍总苷胶囊与昆明山海棠片加白芍总苷胶囊均能较好地治疗RAU,减轻RAU患者临床症状,且沙利度胺加白芍总苷胶囊治疗效果更显著。这种作用可能是通过降低RAU患者血清中升高的TNF-α或(和)升高RAU患者血清中降低的IL-2水平来实现的。更多还原

【Abstract】 Objective:The objective of this study is to evaluate the efficacy of thalidomide for RAU and explore its therapeutic mechanism through the contrastive analysis of the efficacy Thalidomide combined with Total Glucosides of Paeony Capsules which depends on the variation of serum levels of TNF-α and IL-2 in RAU patients before and after treatment. Method:160 cases were randomly divided into two groups. Experimental group were treatmented with Thalidomide combined with Total Glucosides of Paeony Capsules,and control group were treatmented with Tripterygium hypoglaucum combined with Total Glucosides of Paeony Capsules.Observe,record the clinical indicators and then compare the difference of two groups;2 Obtained serum of RAU patients that before and after the treatment of Thalidomide combined with Total Glucosides of Paeony Capsules and Tripterygium hypoglaucum combined with Total Glucosides of Paeony Capsules respectively. ELISA method was applied to detect the content of TNF-α,IL-2. And then test their difference statistically.Result:1Treatment effect of two groups were obvious(P <0.05)and the difference between these two drugs was statistically significant(P <0.05);2RAU patients with serum TNF-α levels were significantly higher than in healthy people,while the IL-2’s were significantly lower,the difference were statistically significant(P <0.05);the variety law are:TNF-α:heavy >light > healthy people(P <0.05);IL-2:heavy < light < healthy people(P <0.05);3The serum levels of TNF-α in the RAU reduced and IL-2 increased significantly after taking the Thalidomide and Tripterygium hypoglaucum(P <0.05),and compared with Tripterygium hypoglaucum,Thalidomide was much more effective(P <0.05). Conclusion:Thalidomide could reduce serum levels of TNF-α or(and) increase the levels of IL-2 which was viewed as its therapeutic mechanism,at the same time it could relieve the clinical symptoms. Also,thalidomide is much more effective than Tripterygium hypoglaucum significantly.更多还原