【摘要】 目的:比较利培酮、奥氮平、奎硫平、阿立哌唑、齐拉西酮、氨磺必利6种抗精神病药对急性期首发精神分裂症患者认知功能的影响。方法:120例精神分裂症首发患者分为6个药物组,每组各20例,分别给予6种抗精神病药治疗,观察12周。采用阳性和阴性症状量表(PANSS)、韦氏成人智力测验(WAIS-RC)、威斯康星卡片分类测验(WCST)、临床记忆量表(CMS)在治疗前后评估疗效及认知功能。结果:与治疗前相比,各药物组PANSS阳性症状、阴性症状及总分在治疗后各时点均明显下降(P<0.05或P<0.01);WAIS-RC、CMS、WCST评分均明显改善(P<0.05或P<0.001);各组间比较,差异无统计学意义。相关分析显示,总智商差值与PANSS总分及阴性症状差值呈正相关性(r=0.559,r=0.755;P<0.01或P<0.001),与阳性症状差值无相关(r=0.148,P>0.05)。结论:6种新型抗精神病药均能改善首发精神分裂症患者的认知功能。更多还原

【Abstract】 Objective: To make a comparison of the effects of the acute treatment with six kinds of antipsychotic drugs,risperidone,olanzapine,quetiapine,aripiprazole,ziprasidone and amisulprid,on the cognitive function in patients with first-episode schizophrenia. Method: One hundred and twenty schizophrenic patients were divided into 6 groups,each group made up of 20 cases. Cases from each group receive medical treatment with one of the six antipsychotic drugs respectively and undergo the medical observation for 12 weeks. Positive and negative syndrome scale( PANSS),Wechsler adult intelligence scale-revised-China( WAIS-RC),Wisconsin card sort test( WCST) and clinical memory scale( CMS) were applied to make an assessment of the patients’ therapeutic effectiveness and the improvement of cognitive function before and after the treatment. Results:After the treatment with different kinds of antipsychotic drugs,the PANSS positive,negative and total treatment scale scores of schizophrenia patients on each group at all time points declined obviously( P < 0. 05 or P < 0. 01). Different index scores of WAIS-RC,CMS and WCST were clearly improved( P < 0. 05 or P < 0. 001). Comparison between groups showed no statistical significance. Pearson correlation indicated that full intelligence quotient difference had a positive correlation with PANSS total score and negative syndrome difference( r = 0. 559,r = 0. 755; P < 0. 01 or P < 0. 001),while no correlation with positive syndrome difference( r = 0. 148,P > 0. 05). Conclusion: The six kinds of newly-developed antipsychotic drugs can improve the cognitive function of first-episode schizophrenia patients.更多还原