【摘要】 目的:通过筛查体检人群幽门螺杆菌(Hp)感染情况,并检测其血清胃蛋白酶原(PG)的含量,探讨Hp感染与血清PG的关系。方法:选取2013年4月~2014年6月间在江苏省人民医院体检的735名受检者,采用HG-IRIS13C红外光谱仪测定Hp感染情况,时间分辨荧光免疫法(TRFIA)检测血清中PG I和PGⅡ水平。结果:血清PG I水平异常组(高于正常组、低于正常组)的Hp阳性率明显高于PG I水平正常组,差异有统计学意义(P<0.05);血清PG II水平高于正常组的Hp阳性率明显高于PG II水平正常组,差异有统计学意义(P<0.05);PG I/II比值低于正常组的Hp阳性率明显高于正常组,差异有统计学意义(P<0.05)。Hp阳性组的血清PG I、PG II水平显著高于阴性组,差异有统计学意义(P<0.05),PG I/Ⅱ比值则显著低于阴性组(P<0.05)。Hp感染与血清PG I、PG II水平呈正相关,与血清PGI/II比值呈负相关。结论:血清PG水平的变化与Hp感染相关。血清PGI、PGII水平升高,PG I/PG II比值下降提示HP感染的可能。更多还原

【Abstract】 Objective To screen the situation of Helicobacter pylori( Hp) infections and detect the level of serum pepsinogen( PG) in physical examination people. Then to study the relation between Hp infections and the level of serum PG. Method A total of 735 subjects who had physical examination in Jiangsu Province Hospital from April 2013 to June 2014 were recruited. The Hp infections were determined by HG-IRIS13 C infrared spectrometer. Fasting serum samples for PG Ⅰ and PGⅡ determination were analyzed by time-resolved fluoroimmunoassay( TRFIA). Results The positivity rate of Hp infection were significantly higher in abnormal PG Ⅰ level group( higher than normal group,lower than normal group) than that innormal PG Ⅰ level group( P < 0. 05). The positivity rate of Hp infection was obviously higher in raised PG Ⅱ level group than that in normal PG Ⅱ level group( P < 0. 05). In reduced PG Ⅰ / Ⅱ ratio group,the positivity rate of Hp infection was obviously higher than that in normal PG Ⅰ / Ⅱ ratio group( P < 0. 05). The PG Ⅰ,PG Ⅱ level of HP-positive group were significantly higher than Hp-negative group( P < 0. 05). PG Ⅱ / Ⅱ ratio were significantly lower than Hp-negative group( P< 0. 05). Hp infection was positively related to serum PG Ⅰ,PG Ⅱ level and negatively related to PGⅠ / Ⅱ ratio. Conclusion Hp infection is related tothe change of PG level. Increased serum PG Ⅰ,PG Ⅱ level and decreased serum PGⅠ / Ⅱ ratio suggest Hp infection.更多还原