【摘要】 目的研究川芎嗪注射液联合米力农治疗慢性阻塞性肺疾病(COPD)并发慢性肺心病急性加重期的临床疗效。方法采用随机、平行对照的研究方法,将98例COPD并发慢性肺心病急性加重期患者随机分成两组。对照组(49例)给予常规治疗,观察组(49例)在常规治疗的基础上加用川芎嗪注射液和米力农,疗程10 d。观察各组症状、体征、心功能、肺动脉压、脑钠肽和D-二聚体水平的变化情况。结果观察组总有效率89.8%,明显优于对照组的67.3%,两组差异比较有统计学意义(P<0.05);观察组肺动脉压、脑钠肽和D-二聚体水平降低程度均明显大于对照组,两组比较差异有统计学意义(P均<0.05)。结论川芎嗪注射液联合米力农治疗COPD并发慢性肺心病急性加重期有更好的疗效。更多还原

【Abstract】 Objective To study the clinical efficacy of ligustrazine injection combined with milrinone on chronic obstructive pulmonary disease( COPD) complicated with acute exacerbation exacerbation of chronic cor pulmonale. Methods Ninety patients with COPD combined with acute exacerbation of chronic cor pulmonale were all given conventional treatment and then were randomly divided into two groups: 49 patients of control group were treated with routine therapy,while 49 patients of observation group were given ligustrazine injection and milrinone on basis of routine therapy. The course of treatment was 7 days. Symptoms and signs of heart failure,heart function,pulmonary artery pressure,brain natriuretic peptide( BNP),and D-Dimer were observed.Results The total effective rates were 89. 8% and 67. 3% respectively in the observation group and in the control group( P <0. 05); and downscale of pulmonary artery pressure( PAP) were distinctly greater than the control group,BNP and D-Dimer in the observation group decreased obviously,the differences were statistically significant compared with control group( P < 0. 05).Conclusion Ligustrazine injection combined with milrnone can be effective on COPD patients complicated with acute exacerbation of chronic cor pulmonary.更多还原