【摘要】 目的探讨在高血压及高血压合并糖尿病人群中心踝指数(CAVI)与心血管危险因素的相关性。方法连续入选原发性高血压患者82例(EH组)及高血压合并糖尿病患者35例(EH+T2DM组),记录性别、年龄、身高、体重、血压、脉压等背景资料。记录心电图,测定CAVI,使用心脏超声仪测定心脏结构,根据Devereux公式计算左室重量指数(LVMI)。并根据Ccockcroft-Gault公式计算肌酐清除率(Ccr)。通过回归分析分析CAVI与各心血管危险因素的相关性。结果 EH+T2DM组、双侧CAVI均明显高于EH组,左右CAVI分别为(8.20±1.26)vs.(7.50±1.20),P=0.005;(8.17±1.29)vs.(7.50±1.22),P=0.009。CAVI与年龄、收缩压、脉压呈正相关(P=0.000,0.028,0.000;r=0.568,0.200,0.328),与肌酐清除率呈负相关(P=0.000,r=-0.444)。年龄、收缩压与CAVI独立相关(P=0.000,0.008;r=0.603,0.464)。结论 CAVI可以作为一种便捷的动脉硬化评价指标,但不同的年龄组应设定不同的正常值。更多还原

【Abstract】 Objective To evaluate the relationship between cardiovascular risk factors and cardio- ankle vascular index( CAVI) in hypertensive and diabetic population. Methods 82 essential hypertensive patients( EH) and 35 hypertensive patients with type 2 diabetic mellitus( EH + T2DM) were enrolled. Clinicaldata,including gender,age,height,body weight,blood pressure,and pulse pressure were collected. ECG and ecocardiography were taken. Urine aliquot and venous blood were collected. Urinary albumin,urine creatinine,serum creatinine were tested. Urinary albumin / creatinine ration( ACR) was calculated. Left ventricular mass index and creatinine clearance were calculated by Devereux fomular and Ccockcroft- Gault formular,respectively. Correlation analysis between CAVI and cardiovascular risk factor were run by SPSS 19. 0. Results Bilateral CAVI were significantly higher in EH + T2 DM group compared to EH group; 8. 20 ± 1. 26 vs.7. 50 ± 1. 20,P = 0. 005; 8. 17 ± 1. 29 vs. 7. 50 ± 1. 22,P = 0. 009,respectively). CAVI was positively correlated with age,SBP,and PP( P = 0. 000,0. 028,0. 000,respectively; r = 0. 568,0. 200,0. 328,respectively). CAVI was negatively correlated with e GFR( P = 0. 000,r =- 0. 444). Age and SBP were independently correlated with CAVI( P =0. 000,0. 008; r = 0. 603,0. 464,respectively). Conclusion CAVI could be used as a convenient way to evaluate arteriosclerosis,but different age group should be set corresponding normal CAVI value.更多还原