【摘要】 目的探讨重度溃疡性结肠炎的病例特点及个体化治疗。方法选取我院治疗的重度溃疡性结肠炎患者79例作为研究对象,分析患者的临床特征、实验室、内镜等检查资料,观察药物治疗转归。结果 79例患者中,广泛结肠病变较为常见,占82.28%;发病期93.67%伴随腹痛症状,88.61%伴随血便,17.72%伴随肠外表现。体格检查显示以腹部压痛症状为主,占82.28%,贫血貌其次,占60.76%。实验室检查结果显示以白蛋白降低、中性粒细胞和C反应蛋白升高为主。内镜检查结果显示,可见大部分患者伴随黏膜慢性炎。78.48%重型结肠患者行激素治疗,疾病治疗总有效率为82.28%,9例药物治疗无效改行手术,占11.39%。随访1年,存活率为97.33%,死亡率为2.74%。结论重型溃疡性结肠病变以广泛结肠病变为主,发病期常以血便、腹部疼痛为主;治疗时应加强对疗效的观察,必要时可行结肠切除术。更多还原

【Abstract】 Objective To explore the clinical characteristics and drug treatment on severe ulcerative colitis.Methods 79 patients of severe ulcerative colitis in the hospital were selected as research object.The clinical features,laboratory,endoscopic and examination data were observed.Results Among 79 patients,extensive lesions of colon were more common,accounting for 82.28%.93.67% patients were accompanied by abdominal pain symptoms at the period of onset,and 88.61% with bloody stool.In addition,17.72% patients had intestinal outside performance.Physical examination revealed to abdominal tenderness symptoms,which accounted for 82.28%,and anaemic accounted for 60.76%.Laboratory examination mainly based on increased albumin and neutral particle cell,and decreased C reaction protein.Endoscopic examination showed that most patients with chronic mucosal inflammation visible.78.48% patients of severe colonic disease underwent hormone treatment,with the total effective rate was 82.28%.9cases who were ineffective treatment underwent surgery,accounting for 11.39%.During the one– year followed-up,the survival rate was 97.33% and the mortality rate was 2.74%.Conclusion Severe ulcerative lesions with extensive colonic lesions often had bloody stool and abdominal pain at the period of onset.Treatment should strengthen the observation on curative effect,and the colon resection must be feasible.更多还原