【摘要】 目的以杭州地区高危妊娠孕妇作为研究对象,探讨胎儿先天性心脏病可能的影响因素。方法先心组45例,非先心组45例,收集有关胎儿先天性心脏病的相关因素信息,进行组间对比研究。利用两样本t检验、χ2检验筛选出的影响因素,并采用Logistic多因素回归分析研究不同影响因素和先心病的关系及关联强度。结果孕妇年龄、孕早期有呼吸道感染及发热史、主动或被动吸烟是先心病的危险因素(OR值分别为86.541,40.845和4.646),服用叶酸是先心病的保护性因素(OR为0.214)。结论在先心病病因仍不明确的条件下,孕早期尽量避免接触各类危险因素,并尽早采取有效的监测是预防先心病的重要措施。更多还原

【Abstract】 Objective:To investigate the relationship between some possible factors and congenital heart diseases(CHD)in the high risk gravidas in Hangzhou city. Methods:Forty-five high risk gravidas in Hangzhou city with fetal CHD were enrolled in this study as the CHD group and the other 45 ones without CHD as the control group. The exposure of related factors during the 3 moths prior to pregnancy to pregnancy in the first 3 months was collected and compared between these two groups. Two sample ttest and chi-square test were used for single factor analysis. Logistic regression was used for multi-factor analysis. Results:The age of the pregnant women,the history of respiratory tract infectivity and fever,and passive or active smoking were the risk factors of fetal CHD(OR:86.541,40.845 and 4.646). However,taking folic acid could be considered as a protective factor of fetal CHD(OR=0.214). Conclusion:Avoiding exposure in some risk factors and effective monitoring could be considered as important methods to prevent fetal CHD.更多还原