【摘要】 目的:评价醋酸曲安奈德局部注射对变应性鼻炎患者血清白介素4(interleukin-4,IL-4)和γ干扰素(interferon-γ,INF-γ)表达水平的影响。方法:60例变应性鼻炎患者随机分成观察组和对照组各30例,对照组予盐酸西替利嗪片10 mg,po,qd,观察组患者双侧中、下鼻甲黏膜下局部注射醋酸曲安奈德治疗。治疗4周后,检测两组患者血清IL-4、IFN-γ水平,比较两组疗效和药品不良反应。结果:观察组总有效率为93.33%,高于对照组的73.33%,但差异无统计学意义(P>0.05)。治疗4周后,观察组IL-4浓度低于对照组(P<0.01),IFN-γ浓度高于对照组(P<0.01)。两组均未发现不能耐受的不良反应或严重不良反应。结论:醋酸曲安奈德局部注射治疗变应性鼻炎疗效较佳,能够降低患者血清IL-4水平,并提高血清IFN-γ水平。更多还原

【Abstract】 Objective: To evaluate the effect of local injection of triamcinolone acetonide on serum levels of interleukin 4( IL-4)and intefferon-γ( INF-γ) in the patients with allergic rhinitis. Methods: Totally 60 cases of allergic rhinitis patients were randomly divided into the observation group and the control group. The control group was given cetirizine hydrochloride tablets orally and the observation group was with local injection of triamcinolone acetonide acetate in the nasal mucosa of middle and inferior nasal concha. The expression of IL-4 and IFN-γ were determined by enzyme-linked immunoadsorbent assay( ELISA) after the 4-week treatment. Results:After the 4-week treatment,the total effective rate was 93. 33% in the observation group and 73. 33% in the control group,however,the difference was not statistically significant( P > 0. 05). IL-4 concentration of the observation group was( 36. 37 ± 8. 32) pg·ml- 1,which was lower than that of the control group( 49. 26 ± 8. 68) pg·ml- 1,and IFN-γ concentration was( 57.21 ±10.34) pg·ml- 1,which was higher than that of the control group( 46. 62 ± 8. 25) pg·ml- 1,and both were with statistically significant difference( P <0. 01). No adverse drug reaction was observed in both groups. Conclusion: Local injection of triamcinolone acetonide acetate in treating allergic rhinitis has better effect through controlling and decreasing the serum level of IL-4 and increasing the serum level of IFN-γ.更多还原