【摘要】 目的:评价喹硫平治疗酒依赖稽延性戒断症状的疗效。方法:将符合ICD-10酒依赖诊断标准的80例患者随机分为喹硫平组和对照组。所有患者在接受1周的苯二氮卓类药物急性戒酒治疗后,喹硫平组给予可变剂量的喹硫平片(200~400mg/d)治疗,对照组给予B族维生素治疗。分别于喹硫平治疗前及4周末进行宾西法尼亚酒精渴求量表(PACS)、视觉模拟渴求量表(VAS)、汉密尔顿抑郁量表(HIAMD)、汉密尔顿焦虑量表(HAMA)和匹兹堡睡眠质量指数(PSQI)测评。结果:与治疗前相比,喹硫平组患者PACS、VAS、HAMD、HAMA及PSQI评分均显著降低(P<0.05);与对照组相比,喹硫平组患者PACS、VAS、HAMD、HAMA及PSQI评分均均显著降低(P<0.05)。结论:喹硫平能有效治疗酒依赖患者急性戒断后的心理渴求、抑郁、焦虑以及失眠等稽延性戒断症状。更多还原

【Abstract】 Objective:To evaluate Quetiapine in the treatment of protracted withdrawal symptoms of patients with alcohol dependence.Methods:80 patients with alcohol dependence were randomly divided into Quetiapine group treated with variable doses of Quetiapine(200 ~400mg/d) and control group treated with vitamin B after acute abstinence with benzodiazepines for 1 week.All the subjects were evaluated with Pennsylvania Alcohol Craving Scale(PACS),Visual Analog Craving Scale(VAS),Hamilton Depression Rating Scale(HAMD),Hamilton Anxiety Rating Scale(HAMA) and Pittsburgh Sleep Quality Index(PSQI) pro-and post-treatment with Quetiapine for 4 weeks.Results:There were significantly decreased in the total scores of PACS,VAS,HAMD,HAMD,and PSQI in Quetiapine group compared with pro-treatment and the control group(P <0.05).Conclusion:Quetiapine can improve the protracted withdrawal symptoms such as craving,anxiety,depression,insomnia in patients with alcohol dependence after acute withdrawal.更多还原