【摘要】 目的观察亚低温疗法对重症病毒性脑炎患儿血清和脑脊液中基质金属蛋白酶(MMPs)的干预作用。方法 120例患儿随机分为实验组和对照组,每组60例。给予所有患儿抗病毒、对症等常规治疗。实验组患儿在常规治疗的基础上,加用5 d的选择性头部亚低温治疗。于治疗前、治疗中(第3天)和治疗后(第7天),测定和比较两组患儿血清和脑脊液中基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-9(MMP-9)的浓度。结果所有患儿血清和脑脊液中MMP-2和MMP-9的浓度都呈3 d后达到高峰、7 d明显下降的趋势。经过亚低温疗法的干预,实验组患儿血清和脑脊液中MMP-2和MMP-9的浓度在治疗中和治疗后均明显低于对照组患儿(P<0.01)。结论选择性头部亚低温疗法可明显抑制重症病毒性脑炎患儿血清和脑脊液中MMP-2和MMP-9的释放。更多还原

【Abstract】 Objective To observe the intervention of hypothermia therapy in the treatment of children with severe viral encephalitis on the levels of matrix metalloproteinases(MMPs) in the serum and cerebrospinal fluid. Methods A total of 120 cases with severe viral encephalitis were randomly divided into the experimental group and the control group, and each group contained 60 cases. All cases were treated with antiviral therapy and symptomatic treatment. The experimental group was treated with additional elective cephalic hypothermia treatment for 5 days. Levels of matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9) in the serum and cerebrospinal fluid before treatment, during treatment(the 3rd day) and after treatment(the 7th day) were detected and compared. Results The tendency of the levels of MMP-2 and MMP-9 in the serum and cerebrospinal fluid of all cases reached the peak at the 3rd day and decreased obviously at the 7th day. The levels of MMP-2 and MMP-9 in the serum and cerebrospinal fluid were significant lower in the experimental group than the control group during the treatment and after the treatment(P<0.01). Conclusion The selective cephalic hypothermia treatment can inhibit the release of the MMP-2 and MMP-9 in the serum and cerebrospinal fluid effectively.更多还原