【摘要】 目的:观察生长抑素联合中药加味大黄承气汤、复方丹参注射液治疗重症急性胰腺炎的疗效。方法:40例重症急性胰腺炎患者,其中对照组20例,单纯采用生长抑素治疗;治疗组20例,采用生长抑素+加味大黄承气汤+复方丹参注射液。观察两组治疗前后急性生理学和慢性健康状态评分系统Ⅱ(APACHEⅡ)评分,血清淀粉酶、血清钙、白介素6(IL-6)、白介素10(IL-10)及白介素18(IL-18)水平的变化,及治疗后局部并发症的发生率和病死率等。结果:治疗后治疗组患者腹痛消失、腹胀消失、排气恢复及平均住院天数较对照组明显缩短,两组比较差异有统计学意义(P<0.05)。治疗后两组血清淀粉酶、白介素6、白介素18及APACHEⅡ评分均较治疗前下降,但治疗组下降幅度大于对照组(P<0.05)。血清钙浓度逐渐增加,且治疗组的增加幅度大于对照组(P<0.05)。两组血清IL-10随着治疗呈下降趋势,但治疗组血清IL-10水平在第10天后又有所增高,高于第5天水平,也高于同期对照组(P<0.05)。治疗组局部并发症发生率低于对照组(P<0.05),两组病死率差异无统计学意义。结论:生长抑素联合加味大黄承气汤及丹参注射液治疗重症急性胰腺炎,可提高治疗效果。更多还原

【Abstract】 Objective: To investigate the effect of therapy with modified Dachengqi decocotion combined with stilamir in severe acute pancreatitis( SAP). Method: Forty patients with SAP were randomly divided into two groups,the treated group treated with the combined therapy and the control group treated by stilamir alone. Serum amylase,calcium concentration,interleukin-6( IL-6),IL-10,IL-18 and acute physiology and chronic health evaluation Ⅱ( APACHEⅡ) score were determined before and after treatment. And the incidence of complication and mortality were assessed. Result: The time of abdominal pain, distention disappearance, air charge recovering,and average hospitalization days in the treated group were significantly shorter than those in the control group respectively( P < 0. 05). Levels of serum amylase,IL-6,IL-18 and APACHE Ⅱscores were lower after treatment in both groups,level of serum calcium concentration were higher after treatment in both groups( P <0. 05). Level of serum IL-10 were lowered after treatment in both groups,but it was higher at 10 days in the treated group again( P < 0. 05). The incidence of local complications in the treated group were significantly lower than those in the control group respectively( P < 0. 05). But the incidence of mortality between the two groups showed no statistical significance. Conclusion: Combined therapy of modified Dachengqi tang and stilamir is a recommended recipe in treatment of SAP,it could obviously improve the efficacy of treatment.更多还原