【摘要】 目的:探讨遗忘型轻度认知功能障碍(amnestic-type mild cognitive impairment,aMCI)患者生活质量及其与认知功能的关系,为制订有效的aMCI临床诊治措施、提高aMCI患者生活质量提供依据。方法:现况调查。对宁波市社区流行病学调查确诊的158例aMCI患者,应用自行设计问卷、简易精神状态检查量表(MMSE)、韦氏记忆量表中国修订版(WMS-RC)、日常生活活动能力量表(ADL)、世界卫生组织生存质量测定量表简表(WHOQOLBREF)等工具进行相关测定。采用SPSS 17.0软件进行统计处理,组间比较计量资料采用t检验、方差分析,相关性采用Spearman秩相关分析。结果:158例aMCI患者以受教育水平分层,各层MMSE得分不同(t=12.642,P<0.01),均数均低于界值。WMS-RC的4个记忆分量表(图片回忆、字词联想、理解记忆和背数)得分均低于60岁以上老年常模组(P<0.01)。158例aMCI患者ADL得分最高分19.94,最低分10.25,平均为15.68±1.74,WHOQOL-BREF总的生存质量及其4个领域得分与成人常模比较,生理领域、心理领域、社会关系领域和总得分均低于常模(P<0.01),环境领域得分高于常模(P<0.01)。MMSE、WMS-RC的4个分量表得分与生存质量生理领域、心理领域、社会关系领域得分呈正相关(P<0.05或P<0.01),与ADL得分呈负相关;MMSE、WMS-RC量表除图片回忆以外的3个分量表得分与环境领域得分呈正相关(P<0.05或P<0.01);MMSE量表、WMS-RC量表除字词联想以外的3个分量表得分与生存质量总得分呈正相关。结论:aMCI患者生存质量低于常模;其生存质量与认知功能密切有关;可以通过改善MCI患者认知提高aMCI患者生存质量。更多还原

【Abstract】 Objective To explore the relationship of aMCI(amnestic-type mild cognitive impairment,aMCI)patients’ qualities of life and cognitive function.Methods We studied 158aMCI patients in communities of Ningbo city.Data were collected by using the questionnaire method with MMSE,WMS-RC,ADL,WHOQOL-BREF,etc.and then calculated with SPSS17.0.ResultsThe one hundred and fifty-eight aMCI patients were stratified by educational level.MMSE scores of different groups had statistical significance(t=12.642,P<0.01).Compared with norm aged over 60,four subscales scores of WMS-RC memory were statistically lower(P<0.01).The highest score of ADL was 19.94,otherwise the lowest score was 10.25,the mean score was 15.68±1.74.Conclusions aMCI patients’ life quality is lower than the norm.By improving the cognition of aMCI patients quality of life can be improved in patients with aMCI.更多还原