【摘要】 肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor-related apoptosis-inducing ligand,TRAIL)能够特异性杀伤肿瘤细胞而不损伤正常组织,是脑胶质瘤基因治疗的理想策略。新近发现以纳米粒子和干细胞作为载体能提高TRAIL的呈递效率,与蛋白酶抑制剂、化疗药物、甘珀酸钠、miRNA和PI3-激酶/mTOR抑制剂等联合使用有助于克服胶质瘤对TRAIL的耐药性,增强TRAIL的抗肿瘤功效。由此可见,TRAIL在脑胶质瘤的治疗中具有较广泛的应用前景。更多还原

【Abstract】 Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL), which can specifically kill tumor cells without damaging normal tissue, has been identifi ed as an ideal gene therapy strategy for glioma. Recent studies revealed that both nanoparticles and stem cells could serve as carriers to improve the delivery effi ciency of TRAIL. In addition, the combination of protease inhibitors, chemotherapy drugs, carbenoxolone sodium, miRNA, PI3-kinase/mTOR inhibitor, and etc, could overcome the glioma resistance to TRAIL and enhance the anti-tumor effect of TRAIL. To sum up, TRAIL shows promising prospects in the treatment of glioma.更多还原