【摘要】 目的对病毒性心肌炎患儿B型脑纳肽(B-type natriuretic peptide,BNP)、左心功能(EF)、C-反应蛋白(CRP)及基质金属蛋白酶-2(MMP-2)的变化进行分析,探讨以上指标与病情严重程度之间的关系。方法 2013年1-7月随机选取医院40例病毒性心肌炎患儿为心肌炎组,同时随机选取30名健康儿童作为对照组,对比两组EF、BNP、CRP、MMP-2的差异;同时根据心肌炎严重程度将心肌炎组分为轻症组28例和重症组12例,对比两组患儿EF、BNP、CRP、MMP-2差异,数据采用SPSS19.0进行分析。结果心肌炎组EF明显低于对照组,而BNP、CRP、MMP-2则明显高于对照组;同时重症组较轻症组,EF更低,BNP、CRP、MMP-2更高;患儿病毒包括脊髓灰质炎病毒6株占15.0%、埃可病毒6株占15.0%、柯萨奇病毒8株占20.0%、流感病毒6株占15.0%、腺病毒6株占15.0%、麻疹病毒4株占10.0%、副流感病毒4株占10.0%。结论病毒性心肌炎患儿EF、BNP、CRP、MMP-2均较健康儿童差,同时随着病情加重,其程度越差。更多还原

【Abstract】 OBJECTIVE To analyze changes of left ventricular function(EF),B-type natriuretic peptide(BNP),Creactive protein(CRP)and matrix metalloproteinase-2(MMP-2)in children with viral myocarditis and explore the relationship between the above indexes and illness severity.METHODS A total of 40children with viral myocarditis during Jan.-Jul.2013were randomly selected as the myocarditis group and 30healthy children as the control group.Differences in EF,BNP,CRP,and MMP-2were compared between the two groups.The myocarditis group was subdivided to the mild group(28children)and the severe group(12children)according to the severity,and differences in EF,BNP,CRP,MMP-2were compared between these two groups.Data were analyzed using SPSS 19.0.RESULTS EF in the myocarditis group was obviously lower than in the control group,while BNP and CRP,MMP-2were significantly higher than in the control group.The severe group had lower EF and higher BNP,CRP,MMP-2compared to the mild group.Patients included 6patients with poliovirus(15%),6patients with echovirus(15%),8patients with coxsackie virus(20%),6patients with influenza virus(15%),4patients with adenovirus(15%),4patients with measles virus(10%),and 4patients with parainfluenza virus(10%).CONCLUSIONEF,BNP,CRP,MMP-2were poorer in children with viral myocarditis compared with healthy children,and the severer the disease,the poorer the level of these indexes.更多还原