【摘要】 目的观察新诊断糖尿病成年男性患者性激素结合球蛋白(SHBG)的变化,探讨其与IR及胰岛早相分泌功能的关系。方法纳入新诊断糖尿病男性患者56例为糖尿病组,另选健康成年男性38名为正常对照组,测定SHBG,进行精氨酸刺激试验。结果两组SHBG、胰岛素抵抗指数(HOMAIR)差异有统计学意义(P<0.01)。相关分析显示,SHBG与HOMA-IR呈负相关(r=-0.219,P<0.05)。Logistic回归分析显示,SHBG是IR的唯一有效自变量(β=-0.75,P<0.05,OR=0.47)。二元Logistic回归分析得出HOMA-IR是糖尿病的危险因素,SHBG是糖尿病的保护因素。胰岛2min分泌高峰值与HOMA-IR呈正相关(β=0.567,P<0.05)。结论新诊断糖尿病成年男性患者存在血清SHBG降低,SHBG与HOMA-IR呈负相关。SHBG是新诊断糖尿病成年男性患者的独立保护因素。胰岛β细胞第一时相分泌功能减退与IR相关,与SHBG无相关性。更多还原

【Abstract】 Objective To observe the change of sex hormone-binding globulin(SHBG)in newly diagnosed adult male diabetic patients,and to explore the relationship of SHBG with insulin resistance(IR) and early phase secretion ofβ-cell. Methods Fifty-six young-middle aged male patients with newly diagnosed diabetes,and another 38male cases were enrolled,SHBG and concurrent L-arginine stimulation test were all detected in two groups. Results The levels of SHBG and HOMA-IR were significantly different between the two groups(P<0.01).SHBG had negative correlation with HOMA-IR(r=-0.219, P<0.05).Logistic regression analysis showed insulin resistance was the only valid factor for SHBG(β=-0.75,P<0.05,OR=0.47).Binary logistic regression analysis showed that HOMA-IR was a risk factor for diabetes,and SHBG was a protective factor for diabetic patients.Both SHBG and control groups reached a peak in 2min,the insulin secretion peak positively correlated with HOMA-IR(β=0.567,P< 0.05). Conclusion The newly diagnosed adult male diabetic patients have insulin resistance.Compared with the control group,the level of SHBG is significantly lower in SHBG group.SHBG is not only a predicting factor for insulin resistance,but also the independent protective factor in newly diagnosed adult male diabetes.Isletβcell with the early phase secretion dysfunction is associated with insulin resistance, but no correlation with SHBG.更多还原