【摘要】 目的:对卵巢储备功能低下结合不孕患者中西医结合治疗后成功妊娠者进行临床观察及疗效机制探讨。方法:回顾性研究2012年~2013年期间复旦大学妇产科医院诊治的不孕合并卵巢功能低下经中西医结合(戊酸雌二醇片+炔雌醇+补肾活血为主中药)治疗后成功妊娠的35例患者,观察治疗前后生殖相关激素的变化。结果:治疗后与治疗前相比,血清卵泡刺激素(FSH)、FSH与黄体生成素(LH)比值降低(P<0.05),雌二醇(E2)、睾酮(T)升高(P<0.05);35例患者成功排卵、受孕。结论:补肾活血中药为主的中西医结合治疗对卵巢储备功能低下引起的不孕有明显疗效,可以改善卵巢功能、提高妊娠率;T可以在一定程度上反映卵巢储备功能,可以作为评价卵巢储备功能的一个重要指标。更多还原

【Abstract】 Objective: To observe the curative effect of integrated traditional Chinese and western medicine in treatment of infertile patients with diminished ovarian reserve function,explore the mechanism. Methods: Thirty- five infertile patients getting successful pregnancy after treatment with integrated traditional Chinese and western medicine( estradiol valerate + ethinyloestradiol + tonifying kidney,promoting blood circulation) in the hospital from 2012 to 2013 were researched retrospectively,the changes of reproductive- related hormones before and after treatment were observed. Results: Compared with before treatment,serum follicle- stimulating hormone( FSH) level and the ratio of FSH /luteinizing hormone( LH) after treatment decreased significantly( P < 0. 05),serum estradiol and testosterone levels increased significantly( P < 0. 05); all the 35 patients got pregnancy successfully. Conclusion: Integrated traditional Chinese and western medicine has obvious curative effect on infertile women with diminished ovarian reserve function,which can improve ovarian function and pregnancy rate; testosterone can reflect ovarian reserve function to a certain extent,which can be used as an important indicator to evaluate ovarian reserve function.更多还原