【摘要】 目的:探讨Survivin原位杂交表达在宫颈癌及癌前病变诊断中的应用效果。方法:宫颈癌患者45例作为观察组,另取宫颈上皮内瘤变45例作为对照Ⅰ组、正常宫颈组织45例作为对照Ⅱ组,所有研究对象给予Survivin原位杂交检测。结果:Survivin在对照Ⅱ组、对照Ⅰ组、观察组表达阳性率分别为2.2%、48.9%和84.4%,组间对比差异有统计学意义(P<0.05)。Survivin在宫颈癌Ⅰ期、Ⅱ期和Ⅲ期的阳性表达率对比差异有统计学意义(P<0.05)。Survivin在宫颈癌高分化组、中分化组及低分化组的阳性表达率对比差异也有统计学意义(P<0.05)。Survivin的表达与淋巴结转移无关(P>0.05)。结论:Suvrvini可在宫颈癌及癌前病变的发生发展中发挥作用,其Survivin表达程度与病期进展和不良组织学分级相一致,可作为预后不良的标志之一。更多还原

【Abstract】 Objective: To explore the application effect of Survivin hybridization expression in situ in diagnosis of cervical cancer and cervical precancerous lesion. Methods: A total of 45 patients with cervical cancer,45 patients with cervical intraepithelial neoplasia(CIN),and 45 patients with normal cervical tissue were selected as observation group,control Ⅰ group,and control Ⅱ group,respectively; all the study objects received Survivin hybridization in situ. Results: The positive expression rates of Survivin in control Ⅱ group,control Ⅰ group,and observation group were 2. 2%,48. 9%,and 84. 4%,respectively,there was statistically significant difference among the three groups(P < 0. 05). There was statistically significant difference in the positive expression rate of Survivin in cervical cancer group among stage Ⅰ subgroup,stage Ⅱ subgroup,and stage Ⅲ subgroup(P < 0. 05). There was statistically significant difference in the positive expression rate of Survivin in cervical cancer group among high differentiation subgroup,moderate differentiation subgroup,and low differentiation subgroup(P < 0. 05). There was no correlation between Survivin expression and lymph node metastasis(P > 0. 05). Conclusion: Suvrvini plays a key role in occurrence and development of cervical cancer and cervical precancerous lesion,and the degree of Survivin expression is related to progression of the disease and adverse histological grade,which can be used as one of the signs of poor prognosis.更多还原