【摘要】 目的探讨瑞芬太尼抑制子痫前期产妇气管插管心血管反应的半数有效浓度(EC50)。方法选择子痫前期产妇30例,静注拉贝洛尔后诱导,瑞芬太尼初始效应室浓度为3 ng/mL。气管插管心血管反应阳性标准:收缩压或舒张压≥160/110 mmHg。采用Probit概率回归法计算瑞芬太尼EC50及其95%可信区间。结果瑞芬太尼抑制气管插管心血管反应的EC50及其95%可信区间为1.93(1.89~1.95)ng/mL。结论瑞芬太尼抑制子痫前期产妇气管插管心血管反应的EC50为1.93 ng/mL。更多还原

【Abstract】 Objective To determine the median effective concentration(EC50) of remifentanyl inhibiting cardiovascular response to tracheal intubation in women with preeclampsia. Methods Thirty women with preeclampsia were enrolled in this study. The target Ce was set at 3 ng/mL. The positive cardiovascular response was defined as the blood pressure ≥160/110 mmHg. The EC50(95% confidence interva1) of cardiovascular responses to tracheal intubation was calculated by Probit analysis. Results EC50(95% confidence interval) of remifentanyl inhibiting cardiovascular response to tracheal intubation was 1.93(1.89~1.95) ng/mL. Conclusion EC50 of remifentanyl inhibiting cardiovascular response to tracheal intubation is 1.93 ng/mL in women with preeclampsia.更多还原