【摘要】 目的观察西酞普兰对急性脑卒中后抑郁患者神经功能恢复的影响。方法选取2008~2012年在我院接受治疗的急性脑卒中后抑郁患者70例,分为观察组和对照组,每组35例,观察组患者给予西酞普兰结合常规的脑卒中治疗,对照组患者给予常规的脑卒中治疗。观察两组患者治疗后3个月的NIHSS评分、HAMD评分、BI指数、MMSE评分、神经肽Y以及血浆P物质、血清脑源性神经营养因子的含量。结果经过3个月治疗后观察组患者的NIHSS评分、HAMD评分较对照组显著下降、MMSE评分、BI指数较对照组显著上升、血浆P物质较对照组明显降低、神经肽Y、血清脑源性神经营养因子含量较对照组显著升高(P均<0.05)。结论西酞普兰有利于急性脑卒中后抑郁患者神经功能的恢复。更多还原

【Abstract】 Objective To investigate the neural functional recovery impact of depression patients after acute stroke after acute stroke by citalopram. Methods Seventy depression patients after acute stroke who were in the department of neurology in our hospital from 2008 to 2012 were chosen as the research objects,they were divided into the control group(cases=35) and the observation group(cases=35) through the computer randomized way.The patients in the control group were given the conventional stroke treatment,but the patients in the observation group were given citalopram on the basis of conventional stroke treatment.The NIHSS score, HAMD scores, BI index, MMSE score, substance P, serum neuropeptide Y and plasma levels of brain derived neurotrophic factor were compared after treatment for 3 months.Results After 3 months,the NIHSS scores,HAMD scores and Plasma substance P in the observation group were lower than that of the control group(P <0.05), MMSE scores,BI index, Neuropeptide Y and serum brain derived neurotrophic factor in the observation group were higher than that of the control group(P<0.05). Conclusion Citalopram is beneficial to the recovery of neural function in depression patients after acute stroke.更多还原