【摘要】 目的对产于湖北随州的石松Lycopodium japonicum的化学成分进行研究。方法用硅胶、反相硅胶、Sephadex LH-20柱色谱和半制备HPLC多种方法分离纯化,通过理化性质和波谱数据解析化合物的结构。结果从石松全草的甲醇提取物中分离得到8个化合物,分别鉴定为21-表千层塔烯二醇(1)、千层塔烯二醇(2)、α-芒柄花醇(3)、serrat-14-en-3β,21β,24-triol(4)、3β,21α-dihydroxyserrat-14-en-16-one(5)、石松三醇(6)、石松四醇(7)、3α,21β,24-trihydroxyserrat-14-en-16-one(8)。结论化合物1~8均为千层塔烯(serratene)三萜,为石松属植物中的特征性化学成分。化合物5为该植物中首次分得。更多还原

【Abstract】 Objective To investigate the chemical constituents in the whole plant of Lycopodium japonicum, native to Suizhou city, Hubei province for the first time. Methods The compounds were isolated and purified by a combination of silica gel, ODS, and Sephadex LH-20 column chromatography and prep-HPLC. Their chemical structures were established by their physicochemical properties and spectral data. Results Eight pentacyclic triterpenoids have been isolated and characterized from the methanol extract of the whole plant, they are 21-episerratenediol(1), serratenediol(2), α-onocerin(3), serrat-14-en-3β, 21β, 24-triol(4), 3β, 21α-dihydroxyserrat-14-en-16-one(5), lycoclavanol(6), lyclaninol(7), and 3α, 21β, 24-trihydroxyserrat-14-en-16-one(8). Conclusion Compounds 1—8 are all serretene triterpenoids, the characteristic chemical constituents in the plants of genus Lycopodium L. Compound 5 is isolated from this plant for the first time.更多还原