【摘要】 目的评价瑞舒伐他汀钙对高血压患者血管活性物质、脉压指数(PPI)及颈动脉内膜中层厚度(IMT)的影响及相关性。方法选择高血压患者80例,随机分成观察组和对照组,每组各40例。观察组在原降压药物的基础上加服瑞舒伐他汀钙(10mg/d),对照组则继续服用原降压药物不变,于治疗前及治疗1个月、6个月、12个月分别检测患者的血清高敏C反应蛋白(hs—CRP)、血同型半胱氨酸(Hcy)、血压、PPI及颈动脉IMT。结果 2组治疗前血压、PPI、血清hs—CRP、Hcy及IMT比较差异无统计学意义(P>0.05)。与治疗前相比,2组治疗1个月后肱动脉的收缩压、PP均有明显的降低(P<0.05),而舒张压无显著改变;对照组PPI在治疗12个月后差异有统计学意义(P<0.05),观察组治疗1个月后PPI有明显的降低(P<0.05)。与对照组相比,观察组治疗6个月后收缩压、PP降低更明显(P<0.05),而PPI治疗1、6、12个月后与同期对照组相比差异均有统计学意义(P<0.05)。观察组治疗后血清hs-CRP、Hcy浓度及IMT均有明显的降低(P<0.05),与对照组相比,观察组hs—CRP治疗1、6、12个月后差异有统计学意义(P<0.05);Hcy治疗6、12个月后差异有统计学意义(P<0.05),IMT治疗6个月后差异有统计学意义(P<0.05)。相关性分析表明,PPI与血清hs-CRP、Hcy浓度及颈动脉IMT均呈正相关(分别为r=0.606、0.583、0.672,P<0.05)。结论瑞舒伐他汀能显著降低高血压患者血管活性物质水平,改善IMT并降低PPI,从而起到抑制炎性反应、缩小动脉粥样硬化斑块,改善血管弹性的作用。更多还原

【Abstract】 Objective To evaluate the effect of rosuvastatin calcium on vasoactive substances,pulse pressure index(PPI) and carotid artery intima-media thickness(IMT) in patients with essential hypertension.Methods Eighty hypertensive patients were randomly divided into the observation group of 40 cases,with the antihypertensive drug and rosuvastatin calcium 10 mg orally 1 time a day,40 patients in control group only received the antihypertensive drug.Before treatment,after 1 months,6 months and 12 months of treatment,2 groups of patient’s high sensitivity C reactive protein(hs-CRP),homocysteine(Hcy),blood pressure,pulse pressure index and intima media thickness were measured and recorded.Results No statistical significance differences of before treatment blood pressure,PPI,serum hs-CRP,Hcy and IMT were found between the 2groups(P > 0.05).Compared with before treatment,after 1 months of treatment,brachial artery systolic blood pressure,PP in the 2 groups were significantly decreased(P <0.05),and diastolic blood pressure did not change significantly;after 12 months of treatment,the PPI in control group revealed statistical significance differences(P < 0.05),after 1 months of treatment,the observation group’s PPI significantly reduced(P <0.05).Compared with the control group,after 6 months of treatment,the observation group’s PP and systolic blood pressure decreased more significantly(P < 0.05),and treatment for 1,6,12 months later,compared with the same period control group,PPI in the observation group had significant difference(P <0.05).The observation group after treatment,serum hs-CRP,Hcy concentration and IMT were significantly decreased(P <0.05).compared with the control group,the observation group’s hs-CRP had significant differences at the treatment of 1,6,12 months(P <0.05);after treatment for 6,12 months,Hcy in the observation group had statistical significance difference(P < 0.05),treatment for 6 months,IMT also had significant difference(P < 0.05).Correlation analysis showed that PPI and serum hs-CRP,the concentration of Hcy and carotid artery IMT were positively correlated(r =0.606,r = 0.583,r =0.672,P <0.05).Conclusion Rosuvastatin can significantly reduce the plasma vasoactive substances in hypertensive patients,improve IMT and reduce PPI,and thus inhibit the inflammatory reaction,reduce atherosclerotic plaque,improve blood vessel elasticity.更多还原