【摘要】 收集胃食管反流病(GERD)患者189例,其中反流性食管炎(RE)患者56例,非糜烂性反流病(NERD)患者133例,以347例健康体检者作为对照组。GERD组及对照组填写反流性疾病问卷(RDQ)、综合医院焦虑抑郁量表(HADS)、匹茨堡睡眠质量指数表(PSQI)。GERD患者接受埃索美拉唑40 mg/d治疗2周。结果显示GERD组焦虑抑郁状态及睡眠障碍的发生率高于对照组(P<0.05);RE患者与NERD患者焦虑抑郁状态及睡眠障碍的发生率差异无统计学意义(P>0.05)。GERD患者焦虑抑郁状态、睡眠障碍与症状严重程度呈正相关。单因素Logistic回归分析显示女性、NERD、焦虑抑郁状态是质子泵抑制剂(PPI)疗效的影响因素,多因素Logistic回归分析显示女性、NERD是PPI疗效的独立预测因素。更多还原

【Abstract】 Reflux disease questionnaire( RDQ),hospital anxiety and depression scale( HADS) and Pittsburgh sleep quality index( PSQI) were filled out by 189 gastroesophageal reflux disease( GERD) patients and 347healthy subjects. The GERD patients were divided into 56 reflux esophagitis( RE) patients and 133 non-erosive reflux disease( NERD) patients. GERD patients were treated with esomeprazole 40 mg /d for 2 weeks. The proportion of anxiety,depression and sleep disorder in GERD patients was significantly higher than that in healthy subjects( P< 0. 05). There was no difference between RE patients and NERD patients in the proportion of anxiety,depression and sleep disorder( P > 0. 05). Anxiety,depression and sleep disorder of GERD patients were positively correlated with the severity of symptoms. Single logistic regression analysis showed that female,NERD,anxiety and depression were risk factors of the efficacy of proton pump inhibitors( PPI). Multivariable logistic regression showed that NERD and female were independent predictors of the efficacy of PPI.更多还原