【摘要】 目的综合评价维生素D受体(vitamin D receptor,VDR)基因多态性与慢性乙型肝炎遗传易感性的关系。方法以"Vitamin D receptor polymorphism"、"VDR polymorphism"、"ApaI"、"TaqI"、"FokI"、"BsmI"和"Hepatitis"、"Hepatitis B"、"HBV"等作为关键词在英文数据库PubMed等中进行检索,同时以"维生素D受体"和"乙肝"、"慢性肝炎"等作为主题词检索中文数据库,最后,利用Stata10.0软件进行Meta分析。结果 VDR-FokI基因多态会显著增加慢性乙肝的发病风险,其杂合(Ff vs.ff)、纯合(FF vs.ff)以及等位基因(F vs.f)遗传模型的相对危险度(odds ratio,OR)和95%置信区间(confidence interval,CI)分别为1.37(1.06~1.76)、2.11(1.59~2.79)和1.49(1.20~1.85),而VDRApaI和VDR-TaqI则未发现其与慢性乙肝的相关性。结论 VDR-FokI基因多态性与慢性乙肝的遗传易感性相关,其F等位基因会增加慢性乙肝的发病风险。更多还原

【Abstract】 Objective To comprehensively evaluate the association between vitamin D receptor(VDR)polymorphisms and genetic susceptibility of chronic hepatitis B.Methods Relevant literatures were searched in the English database PubMed with"vitamin D receptor polymorphism","VDR polymorphism","ApaI","TaqI","FokI","BsmI","hepatitis","hepatitis B"and"HBV"as key words.Moreover,"Vitamin D receptor","hepatitis B"and"chronic hepatitis"were searched as subject words in Chinese databases.The Stata 10.0software was used in the Meta-analysis.Results The VDR-FokI polymorphism could significantly increase the risk of chronic hepatitis B with the odds ratio(OR)(95%confidence interval)being 1.37(1.06-1.76),2.11(1.59-2.79)and 1.49(1.20-1.85)under the heterozygote(Ff vs.ff),homozygote(FF vs.ff)and allelic models(F vs.f).But VDR-ApaI and VDR-TaqI were not found to be associated with chronic hepatitis B.Conclusion The VDR-FokI polymorphism is associated with the susceptibility of chronic hepatitis B and the allele of F may increase the risk of chronic hepatitis B.更多还原