【摘要】 目的:比较不同速度静脉泵注右美托咪啶对老年患者镇静效应及其不良反应的影响。方法:选择择期在椎管内麻醉下行髋关节置换手术的老年患者80例,随机分为4组,D0组为空白对照组,D1、D2和D3组分别以0.5、0.75、1.0μg/(kg·h)静脉恒速泵注右美托咪啶。记录患者给药前及给药后每20分钟的HR、MAP、Sp O2、Ramsay镇静评分和Narcotrend值,对比各组的镇静起效时间、维持时间和不良反应情况。结果:D2、D3组的镇静起效时间明显快于D0及D1组(P<0.05)。D2、D3组的镇静维持时间较D0、D1组明显延长(P<0.05)。4组患者术中使用升压药、阿托品的例数以及Sp O2对比未见显著差异(P>0.05)。结论:以0.75~1.0μg/(kg·h)静脉泵注右美托咪啶对椎管内麻醉下行髋部手术老年患者可产生安全有效的镇静作用。更多还原

【Abstract】 Objective To investigate the sedative effects and the adverse reactions in the elderly patients received different speed of dexmedetomidine(Dex) intravenous infusion. Methods Eighty elderly cases were randomly divided into four groups. Group D0 was the control group, while the group D1, D2 and D3 were the trial groups. The heart rates, blood pressure, Sp O2, Ramsay sedation score and Narcotrend value were recorded.Results The sedation onset time of the D2, D3 group was faster than those in the D0 and D1 groups(P <0.05, respectively), and the duration of sedation in groups D2 and D3 were significantly longer than that in the D0 and D1 groups(P < 0.05). Among the four groups, no significant differences in the incidence of hypotension or bradycardia needed vasopressors or atropine to treat and oxygen saturation were shown(P > 0.05).Conclusion Intravenous infusion of Dex by doses of 0.75 ~ 1.0 μg /(kg·h) during hip surgery in the elderly patients under spinal anesthesia could lead to a safe and effective sedation.更多还原