【摘要】 目的评价季节性流行性感冒疫苗(流感疫苗)对儿童新甲型H1N1流感保护效果。方法选择2013年2~6月期间6~59月龄的实验室确诊流感病例为病例组,在儿童预防接种信息系统中随机选择健康儿童为对照组,进行1∶1匹配的病例对照研究,采用条件Logistic回归计算保护效果。结果本研究共纳入1 250对研究对象。2013年2~6月流感疫苗对6~59月龄儿童的保护效果为57.7%(95%CI:46.6%~66.4%),对36~59月龄儿童的保护效果优于6~35月龄儿童,完全免疫的保护效果优于部分免疫,仅研究年度免疫与两个年度均免疫的儿童的保护效果差异无统计学意义。结论流感疫苗对儿童新甲型H1N1流感具有中等的保护效果,建议儿童每年及时进行全程免疫。更多还原

【Abstract】 Objective To estimate the seasonal influenza vaccine effectiveness for A(H1N1)pdm09 among children.Methods 1 ∶ 1 matched case-control study among children aged 6 ~59 months was conducted. The influenza cases from surveillance sites in Guangzhou were laboratory confirmed during February to Jane 2013. The healthy controls were randomly selected from children aged 6 to 59 months in the Children′s Expanded Programmed Immunization Administrative Computerized System. Vaccine effectiveness was analyzed by conditional logistic regression. Results The vaccination information for 1 250pairs subjects during the study period in Guangzhou were analyzed. We found that the VE for A(H1N1)pdm09 was 57.7%(95%CI:46.6%~66.4%). Influenza vaccination provided more protection for children aged 36-59 months than for younger children; full vaccination provided more protection than partial vaccination. There was no difference between those vaccinated in the study year and those vaccinated in both years. Conclusion This post-licensing study of VE found moderate protection against A(H1N1)pdm09 for vaccinated children aged 6 to 59 months. Annual, full and timely vaccination should be encouraged for children.更多还原