【摘要】 目的:以术后2年PSA复发率评价高危局限期或局部晚期前列腺癌根治性手术后即刻辅助内分泌治疗(AHT)的疗效。方法:回顾性总结在2010年9月至2012年3月在我院泌尿外科确诊为高危局限期或者局部晚期的62例前列腺癌患者。所有患者在术前(腹腔镜或耻骨后前列腺癌根治术)均行MRI、ECT(全身骨显像检查),均未发现有区域盆腔淋巴结及骨转移。其中32例患者(A组)在手术后2周至1个月内给予辅助内分泌治疗(AHT),包括口服及注射药物;30例患者(B组)术后未采取任何处理措施。所有患者在术后每3个月复查1次PSA,每6个月行1次ECT检查,每3个月随访1次(包括患者的药物不良反应、用药持续时间及剂量、生存质量),共计2年。结果:A组中有7例患者生化复发,其2年的总体无生化复发率为78.13%。B组中有14例生化复发,其2年的总体无生化复发率为53.33%(P<0.05)。结论:高危局限期或局部晚期前列腺癌根治性手术后即刻AHT可以提高患者无生化复发生存率,对控制该疾病的进一步发展甚至术后的转移有重要意义。更多还原

【Abstract】 Objective: To evaluate the effect of adjuvant hormonal therapy( AHT) immediately after radical surgery for highrisk organ-confined or locally advanced prostate cancer using the PSA-related biochemical relapse rate within 2 years after surgery.Methods: We retrospectively analyzed 62 cases of high-risk organ-confined or locally advanced prostate cancer. The patients were treated by laparoscopic radical prostatectomy or radical retropubic prostatectomy after MRI and ECT systemic bone imaging examination,which revealed no regional lymph node or bone metastasis. Thirty-two of the patients( group A) received AHT orally or subcutaneously from 2 weeks to 1 months after operation,and another 30( group B) were left untreated. We followed up the patients for 2 years,measuring the serum PSA level every 3 months,performing ECT every 6 months,and recording the adverse reactions,medication duration,and the patients’ quality of life. Results: All the operations were successfully accomplished. The rate of 2-year biochemical relapse-free survival was 78. 13%( 25 /32) in group A and 53. 33%( 16 /30) in group B. Conclusion: AHT immediately after radical surgery can improve the rate of biochemical relapse-free survival of the patients with high-risk organ-confined or locally advanced prostate cancer and check the progression and metastasis of the disease.更多还原