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定量核磁共振(QNMR)技术及其在药学领域的应用进展

Progress in Quantitative Nuclear Magnetic Resonance Technology in Pharmaceutical Applications

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【作者】 张芬芬蒋孟虹沈文斌丁娅

【Author】 Zhang Fenfen;Jiang Menghong;Shen Wenbin;Ding Ya;Department of Pharmaceutical Analysis,China Pharmaceutical University;Shanghai Institute for Food and Drug Control;Pharmaceutical Research Institute,China Pharmaceutical University;

【机构】 中国药科大学药物分析教研室上海市食品药品检验所中国药科大学药物科学研究院

【摘要】 定量核磁共振(Quantitative Nuclear Magnetic Resonance,QNMR)法操作简便,不需要自身对照品即可进行含量测定,准确度高,定性与定量可同时进行,在新药开发、药物的对照品研究、质量控制以及代谢组学等药学领域诸多方面具有显著优势.目前美国药典、英国药典、欧洲药典、日本药局方以及中国药典均已将该技术作为法定标准收载于附录中.本文综述了QNMR的原理、方法及近年来在药学领域的应用进展,并对其应用前景进行了展望.

【Abstract】 Due to the advantages of its feasibility,high accuracy,simultaneous qualitative and quantitative analysis,as well as the content determination without its own reference substance,Quantitative Nuclear Magnetic Resonance( QNMR) has been widely used in various pharmaceutical fields including development of new drug,research of pharmaceutical reference substance,quality control,and metabolomics. Nowadays,this technology has been adopted as the standard method by the United States Pharmacopeia,British Pharmacopeia,European Pharmacopeia,Japanese Pharmacopeia,and Chinese Pharmacopeia. This paper reviews the principles,methods and applications of QNMR and predicts its perspectives.

  • 【文献出处】 南京师范大学学报(工程技术版) ,Journal of Nanjing Normal University(Engineering and Technology Edition) , 编辑部邮箱 ,2014年02期
  • 【分类号】R445.2;R917
  • 【被引频次】38
  • 【下载频次】1941
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