【摘要】 目的 通过检测老年空腹血糖调节受损（IFG）和2型糖尿病患者的血清硫化氢（H₂S）水平,探讨气体分子H₂S在老年空腹血糖调节受损和2型糖尿病中的临床意义。方法 2型糖尿病患者66例,空腹血糖调节受损患者36例,正常对照组33例,检测入选者的血清H₂S浓度。结果 与对照组相比,空腹血糖调节受损患者和2型糖尿病患者HOMA-IR指数明显升高[（3.24±0.93）、（2.34±1.12）比（1.70±1.10）,P<0.05]、HOMA-β指数降低[（76.41±26.20）、（36.13±23.37）比（93.00±40.46）,P<0.05],血清H₂S水平明显升高[（60.93±12.95）、（63.64±10.96）比（50.07±10.85）μmol/L,P<0.05]。Pearson相关分析结果显示,H₂S浓度与空腹血糖调节受损组和糖尿病组患者HOMA-β均呈显著负相关（γ值分别为-0.65、-0.69,P<0.05）,与HOMA-IR均呈显著正相关（γ值分别为0.73、0.76,P<0.05）。结论 内源性H₂S可能通过抑制β细胞功能和增强胰岛素抵抗参与空腹血糖调节受损和2型糖尿病的发病过程。更多还原

【Abstract】 Objective To investigate clinical implication of the gasotransmitter hydrogen sulfide（H₂S） in elderly patients with impaired fasting glucose（IFG）and type 2 diabetes mellitus（T2DM） patients by detecting the serum H₂S levels.Methods Sixty-six Type 2 diabetes mellitus patients,thirty-six patients with impaired fasting glucose and thirty-three healthy served as controls were selected.Serum H₂S concentration were detected.Results Compared with controls,patients with impaired fasting glucose and type 2 diabetes mellitus had significantly higher HOMA-IR index[（3.24 ±0.93）,（2.34 ± 1.12） versus（1.70 ±1.10）,P<0.05].lower HOMA-β index[（76.41 ±26.20）,（36.13 ±23.37） versus（93.00 ±40.46）,P < 0.05],higher serum H₂S level[（60.93 ± 12.95）,（63.64 ± 10.96） versus（50.07 ±10.85） μmol/L,P < 0.05].Pearson correlation analysis indicated that H₂S was negatively correlated with HOMA-β in IFG and T2 DM patients（γ =- 0.65,- 0.69,respectively P < 0.05） but positively with HOMA-IR（γ =0.73,0.76,respectively P<0.05）.Conclusion Endogenous H₂S may be involved in the pathogenesis of impaired fasting glucose and T2 DM by inducing p-cell function and enhancing insulin resistance.更多还原