【摘要】 目的:探讨抑郁症患者血清肿瘤坏死因子-α(TNF-α)水平与伴有的躯体疼痛症状的关系。方法:对42例伴有躯体疼痛症状的抑郁症患者(研究组)和79例不伴有躯体疼痛症状的抑郁症患者(对照组)测定血清TNF-α水平,并采用汉密尔顿抑郁量表(HAMD-24)、汉密尔顿焦虑量表(HAMA)、视觉模拟评分(VAS)分别评估患者的抑郁症状、焦虑症状、躯体疼痛症状的程度,并进行相关性分析。结果:研究组血清TNF-α水平[(29.6±4.8)ng/L]显著高于对照组[(27.5±4.2)ng/L](t=2.491,P=0.027);经协方差分析调整影响因素后,两组血清TNF-α水平差异仍有统计学意义(F=3.855,P=0.036)。相关分析显示,研究组血清TNF-α水平与VAS评分、HAMD评分、HAMA评分呈正相关(r=0.362,P=0.018;r=0.408,P=0.006;r=0.336,P=0.038),对照组血清TNF-α水平与HAMD评分正相关(r=0.307,P=0.029)。结论:伴有躯体疼痛的抑郁症患者血清TNF-α水平增高,并可能与躯体疼痛症状的发生有关。更多还原

【Abstract】 Objective: To investigate the relationgship between the tumor necrosis factor-α( TNF-α) and the somatic pain in patients with major depression. Method: Depressive patients with complains of somatic pain( study group,cases 42) were detected the serum level of TNF-α and their severity of depression,anxiety and pain symptoms were evaluated by Hamilton depression scale( HAMD 24-items),Hamilton anxiety scale( HAMA) and visual analogue scale( VAS) respectively,and compared with depressive patients without complains of somatic pain( control group,79 cases). Results: The serum level of TNF-α was significantly higher in study group[( 29. 6 ± 4. 8) ng /L]than that in control group [( 27. 5 ± 4. 2) ng /L]( t = 2. 491,P = 0. 027).In an analysis of covariance,the difference was still significant after adjusted by influencing factor( F = 3. 855,P = 0. 036). There was a positive relationship between serum level of TNF-α and scores of VAS( r = 0. 362,P = 0. 018),HAMD( r = 0. 408,P = 0. 006) or HAMA( r = 0. 336,P = 0. 038) in study group. A similar relationship between serum level of TNF-α and score of HAMD( r = 0. 307,P = 0. 029) was detected in control group. Conclusion: The serum level of TNF-α depressive patients is significantly higher,which magbe correlated to the symptoms in pathophysiological mechanisms of somatic pain.更多还原