【摘要】 目的 探讨乙二醛酶Ⅰ(GloⅠ)基因rs1049346 G/A多态性和耐药性癫痫的相关性。方法 收集67例汉族耐药性癫痫患者和69例汉族非耐药性癫痫患者。采用SNaPshot方法 检测患者外周血GloⅠ基因rs1049346 G/A多态性。结果 耐药组GG、GA、AA基因型分别占6.0%,49.3%,44.7%,非耐药组分别占7.2%,53.6%,39.1%,总体差异无统计学意义(x~2=0.46,P=0.79)。耐药组等位基因G、A频率分别为30.6%,69.4%,非耐药组患者分别为34.1%,65.9%,差异也无统计学意义(CR=0.85,95%CI 0.51~1.42,x~2=0.37,P=0.54)。结论 GloⅠ基因rs1049346 G/A多态与汉族癫痫耐药可能无相关性。更多还原

【Abstract】 Objective To investigate the correlation of glyoxalase Ⅰ(Glo Ⅰ) gene rsl049346 G/A and drug-resistant epilepsy(DRE).Methods The associations between rsl049346 polymorphisms of the Glo I gene and the possible risk of DRE were assessed among 67 patients with DRE and 69 matched patients with non-drug- resistant epilepsy(NDRE) of Han in a case-control study.Results GG,GA,AA genotypes accounted for 6.0%,49.3%,44.7%,and 7.2%,53.6%,39.1%in DRE group and NDRE group respectively(x~2= 0.46,P = 0.79).Allele G,A frequencies were 30.6%,69.4%and34.1%,65.9%in DRE group and NDRE group respectively(OR = 0.85,95%CI 0.51-1.42,x~2 =0.37,P = 0.54).Conclusions Maybe there is no association between rsl049346 G/A polymorphism of Glo Ⅰ gene and DRE in Han.更多还原