【摘要】 目的:探讨男性因素对宫腔内人工授精(IUI)临床妊娠率的影响。方法:回顾性分析239对不孕夫妇行472个IUI周期的资料,分析男方年龄(<30岁,30~35岁,≥35岁)、精子正常形态百分率(正常精子形态≥15%,10%~15%,5%~10%,≤4%)及精液处理后前向运动精子总数(PTMS)[<2×106,(2~15)×106,(5~10)×106,(10~20)×106,≥20×106]对IUI临床妊娠率的影响。结果:472个IUI周期共获得80例临床妊娠,周期妊娠率16.95%,累积妊娠率33.47%。男方年龄≥35岁IUI组临床妊娠率显著下降,仅为10.4%(14/134);重度畸形精子症组周期临床妊娠率为8.4%(7/83),低于其他各组,差异有统计学意义(P<0.05)。结论:IUI治疗过程中要充分考虑男方年龄对治疗结果的影响,当精子正常形态百分率<5%或PTMS<2×106时,IUI临床妊娠率显著下降,建议行体外受精-胚胎移植/胞浆内单精子注射-胚胎移植治疗以改善妊娠结局。更多还原

【Abstract】 Objective: To assess the effects of male factors on the clinical pregnancy rate of intrauterine insemination(IUI). Methods: The data of 472 IUI cycles from January 2012 to April 2013 in our center were retrospectively analyzed. These cycles were divided into three groups according to male age(<30,30~35,≥35 years),four groups according to the percentage of normal morphological spermatozoa(normal: ≥15%;mild, moderate and severe abnormal:10%-15%,5%-10%, ≤4%), or five groups according to the processed total motile sperm count(PTMS)(<2 ×106,(2-5) ×106,(5-10) ×106,(10-20) ×106, ≥20 ×106). Then the clinical pregnancy rates were compared. Results:A total of 80 clinical pregnancies were obtained,for a pregnancy rate per cycle of 16.95% and accumulative rate 33.47%. The clinical pregnancy rate in the ≥35 years old group was 10.4%,in severe abnormal group was 8.4%. These rates were significantly lower than those of other groups( P <0. 05). Conclusions : Male factors such as age, the percentage of normal morphological spermatozoa, and PTMS should be considered during IUI therapy. Those couples with male age ≥35 years, severe abnormal spermatozoa, or PTMS <2×106, should be advised to treat with IVF-ET or ICSI-ET.更多还原