【摘要】 目的:探讨不同剂量米非司酮治疗围绝经期功能失调性子宫出血疗效,为临床治疗策略的制订提供参考。方法:选取在我院妇科门诊就诊的120例围绝经期功能性子宫出血的患者,将其随机分为观察组和对照组各60例。观察组的患者采用每天12.5mg的剂量服用米非司酮片,对照组的患者采用每天6.25mg的剂量服用米非司酮片,连续服用90天。对比两组患者的临床疗效,不良反应,血清雌二醇、黄体酮以及促黄体激素水平以及子宫内膜厚度的变化情况。结果:经过治疗后,观察组的痊愈率为83.33%(50/60),显著高于对照组63.33%(38/60)。观察组有4例患者出现乏力、恶心、眩晕症状,不良反应发生率为6.67%,对照组有3例患者出现乏力、恶心、眩晕症状,不良反应发生率为5.00%,两组不良反应发生情况比较,差异不具有统计学意义(P>0.05)。两组患者治疗后的血清雌二醇、黄体酮以及促黄体激素水平均治疗前有显著下降,P<0.05;观察组治疗后的血清雌二醇、黄体酮以及促黄体激素水平显著低于对照组;两组患者用药3个月后,子宫内膜厚度均有显著的下降,差异均有统计学意义(P<0.05)。两组患者治疗3个月后的子宫内膜厚度的对比,其差异没有统计学意义。结论:采用每天12.5mg的米非司酮口服的方案治疗围绝经期功能失调性子宫出血可以提高临床疗效,且安全性高,不良反应小,值得在临床上进一步推广应用。更多还原

【Abstract】 Objective:To investigate the effect of different doses of mifepristone in treatment of perimenopausal dysfunctional uterine bleeding, and to provide reference for clinical treatment strategies.Methods:120 patients with climacteric dysfunctional uterine bleeding were selected in our hospital.They were randomly divided into observation group and control group with 60 cases in each. The patients in the observation group were treated with daily 12.5mg doses of mifepristone tablets, while in the control group were treated by 6.25mg daily doses of mifepristone tablets, taking 90 days in a row. The clinical curative effect, adverse reaction, serum estradiol, progesterone and luteinizing hormone levels and changes in endometrial thickness of both groups were compared.Results:After treatment, the cure rate of the observation group was 83.33%(50/60), significantly higher than the control group 63.33%(38/60). 4 cases patients with fatigue, nausea,dizziness, the incidence of adverse reaction was 6.67% in the observation group, while in the control group, 3 cases patients with fatigue, nausea, dizziness, the incidence of adverse reaction was 5%, the difference was not statistically significance(P>0.05).The serum levels of estradiol, progesterone and luteinizing hormone levels showed a significant decline in the both groups after treatment; the serum levels of estradiol, progesterone and luteinizing hormone levels in the observation group were significantly lower than those in the control group; the endometrial thickness were significantly decreased in both groups, the difference was statistical significance(P<0.05). Conclusion:Treatment with oral mifepristone 12.5mg every day of perimenopausal dysfunctional uterine bleeding, it can improve the clinical curative effect, and high safety, less adverse reactions, it is worth popularizing in clinic.更多还原