【摘要】 [目的]探讨如何利用植物多糖制备药用硬壳胶囊。[方法]以超低黏度海藻酸钠(SA)、羧甲基纤维素钠(CMC)、聚乙二醇-400(PEG-400)等作为材料制作植物多糖型药用胶囊硬壳。分别选取海藻酸钠、CMC以及PEG-400进行单因素试验分析成膜性、确定材料的配比范围。[结果]单因素试验表明,SA为12%、CMC为2%、PEG-400∶SA为1.25%时制作的药用胶囊硬壳拉伸强度最大,根据这些数据设计17组试验进行响应面分析,结果表明当SA为12.14%、CMC为2.08%、PEG-400∶SA为1.25%时拉伸强度最大,最适合做胶囊壳。验证性试验表明,按此配方常温溶胶混合制作的胶囊壳强度符合设计要求。[结论]研究可为我国利用植物多糖生产制备胶囊壳提供参考依据。更多还原

【Abstract】 [Objective]To study preparation of medicinal hard capsule by plant polysaccharide. [Method]The plant polysaccharide type medicinal capsule shell was made with the ultra low viscosity sodium alginate( SA),sodium carboxymethyl cellulose( CMC) and polyethylene glycol-400( PEG-400). The optimal proportion of sodium alginate,CMC and PEG-400 was determined by single factor experiment. [Result]The results of single factor experiment show that sodium alginate,sodium carboxymethyl cellulose and PEG-400 concentration is 12%,2%and 1. 25% respectively. The optimal proportion of sodium alginate,sodium carboxymethyl cellulose and PEG-400 was determined by response surface analysis. The results show that tensile strength of the plant polysaccharide type medicinal capsule shell is the maximum when SA is12. 14%,CMC is 2. 08%,PEG-400 ratio SA is 1. 25%. The formula is most suitable for the capsule shell. Validation experiments were carried out according to the formula. The strength of capsule shell meets requirements. [Conclusion] The study can provide reference basis for preparation of medicinal hard capsule by plant polysaccharide.更多还原